Distinct expression and clinical value of aquaporin 4 in children with hand, foot and mouth disease caused by enterovirus 71.

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  • Additional Information
    • Source:
      Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
    • Publication Information:
      Publication: New York Ny : Wiley-Liss
      Original Publication: New York, Liss.
    • Subject Terms:
      Aquaporin 4/*blood ; Aquaporin 4/*cerebrospinal fluid ; Enterovirus A, Human/*isolation & purification ; Hand, Foot and Mouth Disease/*virology; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Child, Preschool ; Enterovirus Infections ; Female ; Hand, Foot and Mouth Disease/blood ; Hand, Foot and Mouth Disease/cerebrospinal fluid ; Humans ; Infant ; Interleukin-6/blood ; Male ; Norepinephrine/blood ; Phosphopyruvate Hydratase/blood ; Prognosis ; ROC Curve ; Severity of Illness Index
    • Abstract:
      Brain dysfunction is a prerequisite for critical complications in children with hand, foot, and mouth disease (HFMD). Aquaporin 4 (AQP-4) may be involved in the pathological process of cerebral oedema and injury in children with severe and critical HFMD. This study aimed to assess the association of AQP-4 with the severity of enterovirus 71 (EV71)-associated HFMD. Children with EV71-infected HFMD were divided into a common group (clinical stage 1), a severe group (clinical stage 2), and a critical group (clinical stage 3) according to Chinese guidelines. The levels of AQP-4, interleukin-6 (IL-6), norepinephrine (NE), and neuron-specific enolase (NSE) before and after treatment were tested. Serum AQP-4, IL-6, NE, and NSE levels showed significant differences among the critical, severe, and common groups before and after treatment (P < 0.01). No significant differences in AQP-4 levels in cerebrospinal fluid (CSF) were observed between the critical and severe groups before and after treatment, but the CSF AQP-4 levels in these two groups were higher than those in the common group before treatment (P < 0.01). Serum AQP-4 levels, but not CSF AQP-4 levels, closely correlated with serum IL-6, NE, and NSE levels. These results suggest that the level of AQP-4 in serum, but not in CSF, is a candidate biomarker for evaluating the severity and prognosis of EV71-associated HFMD.
      (© 2019 Wiley Periodicals, Inc.)
    • Contributed Indexing:
      Keywords: aquaporin 4 (AQP-4); enterovirus 71 (EV71); hand, foot, and mouth disease (HFMD); inflammation
    • Accession Number:
      0 (Aquaporin 4)
      0 (Biomarkers)
      0 (Interleukin-6)
      EC 4.2.1.11 (Phosphopyruvate Hydratase)
      X4W3ENH1CV (Norepinephrine)
    • Publication Date:
      Date Created: 20190404 Date Completed: 20220209 Latest Revision: 20220209
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/jmv.25475
    • Accession Number:
      30942492