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Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP.
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- Author(s): Andreazza AC;Andreazza AC;Andreazza AC; Laksono I; Laksono I; Fernandes BS; Fernandes BS; Toben C; Toben C; Lewczuk P; Lewczuk P; Lewczuk P; Riederer P; Riederer P; Riederer P; Kennedy SH; Kennedy SH; Kapogiannis D; Kapogiannis D; Thibaut F; Thibaut F; Gerlach M; Gerlach M; Gallo C; Gallo C; Kim YK; Kim YK; Grünblatt E; Grünblatt E; Grünblatt E; Grünblatt E; Grünblatt E; Grünblatt E; Yatham L; Yatham L; Berk M; Berk M; Baune BT; Baune BT; Baune BT
- Source:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2019 Jun; Vol. 20 (5), pp. 340-351. Date of Electronic Publication: 2019 Mar 25.- Publication Type:
Journal Article; Practice Guideline- Language:
English - Source:
- Additional Information
- Source: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE
- Publication Information: Publication: London : Informa Healthcare
Original Publication: Glasgow : WFSBP, 2000- - Subject Terms: Biomarkers/*blood ; Blood Specimen Collection/*standards ; Mental Disorders/*diagnosis ; Neurodegenerative Diseases/*diagnosis; Advisory Committees ; Biological Psychiatry/methods ; Consensus ; Humans ; Mental Disorders/blood ; Neurodegenerative Diseases/blood ; Reproducibility of Results ; Societies, Medical/standards
- Abstract: Recently, there has been a major shift in the field of psychiatry towards the exploration of complex relationships between blood-based biomarkers and the pathophysiology of psychiatric and neuropsychiatric disorders. However, issues with study reproducibility, validity and reliability have hindered progress towards the identification of clinically relevant biomarkers for psychiatry. The achievement of laboratory validity is a crucial first step for the posterior development of clinical validity. There is evidence that the variability observed in blood-based research studies may be minimised with the implementation of standardised pre-analytical methods and uniform clinical protocols (i.e., pre-venipuncture). It has been documented that errors made in the pre-analytical phase account for 46-68.2% of laboratory testing errors. Thus, standardising clinical assessment, ethical procedures and pre-analytical phase of clinical research is essential for the reproducibility, validity and reliability of blood marker assessment, and reducing the risk of invalid test results. Various other areas of research have already moved towards guidelines for the standardised collection of blood-based biomarkers. Here we aim to provide a set of guidelines that we believe would improve biomarker research: (1) pre-venipuncture information and documentation, (2) ethics of participant consent and (3) pre-analytical methods. Ultimately, we hope this will assist study planning and will improve data comparison across studies allowing for the discovery of biomarkers in psychiatry with both laboratorial and clinical validity.
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Clin Biochem. 2010 Jan;43(1-2):4-25. (PMID: 19822139) - Grant Information: Z99 AG999999 United States ImNIH Intramural NIH HHS
- Contributed Indexing: Keywords: Biomarkers; guidelines; reliability; standardisation; validity
- Accession Number: 0 (Biomarkers)
- Publication Date: Date Created: 20190326 Date Completed: 20200707 Latest Revision: 20210109
- Publication Date: 20221213
- Accession Number: PMC6728424
- Accession Number: 10.1080/15622975.2019.1574024
- Accession Number: 30907211
- Source:
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