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Systematic analysis of the Myxococcus xanthus developmental gene regulatory network supports posttranslational regulation of FruA by C-signaling.
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- Author(s): Saha S;Saha S; Patra P; Patra P; Igoshin O; Igoshin O; Kroos L; Kroos L
- Source:
Molecular microbiology [Mol Microbiol] 2019 Jun; Vol. 111 (6), pp. 1732-1752. Date of Electronic Publication: 2019 Apr 06.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE
- Publication Information: Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-
- Subject Terms: Gene Regulatory Networks* ; Signal Transduction*; Bacterial Proteins/*metabolism ; Myxococcus xanthus/*genetics ; Transcription Factors/*metabolism; Bacterial Proteins/genetics ; Binding Sites ; Computing Methodologies ; DNA, Bacterial/metabolism ; Gene Expression Regulation, Bacterial ; Mutation ; Myxococcus xanthus/metabolism ; Promoter Regions, Genetic ; Protein Binding ; RNA Processing, Post-Transcriptional ; Transcription Factors/genetics
- Abstract: Upon starvation Myxococcus xanthus undergoes multicellular development. Rod-shaped cells move into mounds in which some cells differentiate into spores. Cells begin committing to sporulation at 24-30 h poststarvation, but the mechanisms governing commitment are unknown. FruA and MrpC are transcription factors that are necessary for commitment. They bind cooperatively to promoter regions and activate developmental gene transcription, including that of the dev operon. Leading up to and during the commitment period, dev mRNA increased in wild type, but not in a mutant defective in C-signaling, a short-range signaling interaction between cells that is also necessary for commitment. The C-signaling mutant exhibited ~20-fold less dev mRNA than wild type at 30 h poststarvation, despite a similar level of MrpC and only 2-fold less FruA. Boosting the FruA level twofold in the C-signaling mutant had little effect on the dev mRNA level, and dev mRNA was not less stable in the C-signaling mutant. Neither did high cooperativity of MrpC and FruA binding upstream of the dev promoter explain the data. Rather, our systematic experimental and computational analyses support a model in which C-signaling activates FruA at least ninefold posttranslationally in order to commit a cell to spore formation.
(© 2019 John Wiley & Sons Ltd.) - Accession Number: 0 (Bacterial Proteins)
0 (DNA, Bacterial)
0 (FruA protein, Myxococcus xanthus)
0 (MrpC protein, Myxococcus xanthus)
0 (Transcription Factors) - Publication Date: Date Created: 20190322 Date Completed: 20200214 Latest Revision: 20200214
- Publication Date: 20231215
- Accession Number: 10.1111/mmi.14249
- Accession Number: 30895656
- Source:
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