Maximum morning home systolic blood pressure is an indicator of the development of diabetic nephropathy: The KAMOGAWA-HBP study.

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  • Additional Information
    • Source:
      Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia
    • Subject Terms:
      Biomarkers/*analysis ; Blood Pressure/*physiology ; Diabetes Mellitus, Type 2/*physiopathology ; Diabetic Nephropathies/*epidemiology ; Monitoring, Physiologic/*methods ; Systole/*physiology; Aged ; Blood Glucose/analysis ; Circadian Rhythm ; Female ; Follow-Up Studies ; Humans ; Incidence ; Japan/epidemiology ; Male ; Middle Aged ; Prognosis ; Prospective Studies
    • Abstract:
      Aims/introduction: The maximum value of home systolic blood pressure is correlated with damage to target organs, including diabetic nephropathy. However, the precise relationship between the development of diabetic nephropathy and maximum home systolic blood pressure has not been elucidated.
      Materials and Methods: In this prospective 2-year cohort subanalysis of the KAMOGAWA-HBP study, the patient population was 477 Japanese patients with normoalbuminuria. We investigated the effects of mean and maximum home blood pressure on the development of diabetic nephropathy, which we defined as a urinary albumin excretion value ≥30 mg/g creatinine. Among the 477 patients, 67 developed diabetic nephropathy.
      Results: In our multivariate logistic regression analyses, the maximum morning home systolic blood pressure was significantly positively associated with the development of diabetic nephropathy after adjusting for patient sex and age, smoking status, the diabetes mellitus duration, body mass index, creatinine, total cholesterol, hemoglobin A1c, and antihypertensive medication use (odds ratio 1.21, 95% confidence interval 1.03-1.42, P = 0.021).
      Conclusions: Maximum home blood pressure can be identified at a glance, and its measurement would thus be helpful to healthcare providers who treat patients with diabetes and normoalbuminuria.
      (© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
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    • Grant Information:
      Japanese Study Group for Physiology and the Management of Blood Pressure; Astellas Foundation for Research on Metabolic Disorders; Grant-in-Aid for Young Scientists (B)
    • Contributed Indexing:
      Keywords: Diabetic nephropathy; Hypertension; Maximum home blood pressure
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20190319 Date Completed: 20200413 Latest Revision: 20231014
    • Publication Date:
      20240628
    • Accession Number:
      PMC6825917
    • Accession Number:
      10.1111/jdi.13040
    • Accession Number:
      30884176