Identifying generalized anxiety disorder using resting state habenular circuitry.

Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE

Original Publication: Secaucus, NJ : Springer

Habenula*; Anxiety Disorders/diagnostic imaging ; Cerebral Cortex ; Humans ; Magnetic Resonance Imaging ; Prefrontal Cortex/diagnostic imaging

Studies identify the habenula as a key subcortical component in anxiety, with a role in predicting error coding within the evaluative system. However, no clinical reports of generalized anxiety disorder (GAD) describe resting state functional connectivity of habenular circuits. We hypothesized that resting-state functional connectivities of habenula would show differences in neuroanatomical correlates of the evaluative system (prefrontal cortex, habenula) of patients with GAD. We obtained 22 patients with GAD and 21 HCs, matched for gender, age, and years of education. Resting-state functional connectivity of the habenula was assessed using a seed-based template imposed on whole brain MRI, which provided an objective and semi-automated segmentation algorithm in MNI space. Patients with GAD demonstrated enhanced connectivities in the bilateral premotor cortex, right ventrolateral prefrontal cortex, medial frontal cortex, as well as the left orbitofrontal cortex, and reduced connectivities in the left posterior cingulate cortex, and right pulvinar. Moreover, striking differences of abnormal connectivities between groups were observed via analysis of receiver operating characteristic curves (ROC) of statistically significant. These results including ROC curves suggest the potential importance of the habenula in evaluating and deciding to personally relevant reward-related information.

81571344 National Natural Science Foundation of China; 81201064 National Natural Science Foundation of China; 81871344 National Natural Science Foundation of China; BK20161109 Natural Science Foundation of Jiangsu Province; 18KJB190003 Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China; BE20156092015 key research and development program (Social Development) project of Jiangsu province

Keywords: Evaluation system; Generalized anxiety disorder; Habenula; Resting-state functional connectivity; Reward circuit

Date Created: 20190315 Date Completed: 20210427 Latest Revision: 20210427

20231215

10.1007/s11682-019-00055-1

30868402