Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission.

Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.

Glutamic Acid/*genetics ; Pharmacogenetics/*methods ; Polymorphism, Single Nucleotide/*physiology ; Receptors, Glutamate/*genetics ; Substance-Related Disorders/*genetics ; Synaptic Transmission/*physiology; Animals ; Glutamic Acid/metabolism ; Humans ; Pharmacogenetics/trends ; Polymorphism, Single Nucleotide/drug effects ; Receptors, Glutamate/metabolism ; Substance-Related Disorders/metabolism ; Synaptic Transmission/drug effects

Multiple studies provide evidence to support dysfunction of glutamate neurotransmission in the pathogenesis of drug dependence. Pharmacogenetic investigation of glutamate-related genes has provided further support for the involvement of this neurotransmitter in the risk of, and consequences of, drug abuse and dependence. This paper aims to provide a brief review of these association studies. Findings involving single nucleotide polymorphisms (SNPs) in glutamate receptor genes (GRIN, GRIA) and glutamate transporter genes (SLC1A, SLC17A) are reviewed as potential risk factors. As yet a clear perspective of the functional consequences and interactions of the various reported findings is lacking.
(Copyright © 2019. Published by Elsevier B.V.)

Keywords: Drugs of abuse; GRIA; GRIN; Gene polymorphism; Psychosis; SLC17A; SLC1A

0 (Receptors, Glutamate)
3KX376GY7L (Glutamic Acid)

Date Created: 20190306 Date Completed: 20210419 Latest Revision: 20210419

20221213

10.1016/j.neulet.2019.02.046

30836121