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Normal Values for Parotid Gland and Submandibular-Sublingual Salivary Gland Complex Uptake of 99mTechnetium Pertechnetate using SPECT in Mice with Respect to Age, Sex, and Circadian Rhythm.
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- Author(s): Huang EL;Huang EL; Steffen IG; Steffen IG; Lukas M; Lukas M; Huang K; Huang K; Aschenbach JR; Aschenbach JR; Eary JF; Eary JF; Brenner W; Brenner W; Beindorff N; Beindorff N
- Source:
Nuklearmedizin. Nuclear medicine [Nuklearmedizin] 2019 Feb; Vol. 58 (1), pp. 39-49. Date of Electronic Publication: 2019 Feb 15.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Transliterated Title: Normwerte für den Uptake von 99mTechnetium-Pertechnetat in der Parotis und dem Submandibular-Sublingualen-Speicheldrüsenkomplex bei der Maus in Abhängigkeit von Alter, Geschlecht und circadianem Rhythmus.
- Source: Publisher: Thieme Country of Publication: Germany NLM ID: 7609387 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-6407 (Electronic) Linking ISSN: 00295566 NLM ISO Abbreviation: Nuklearmedizin Subsets: MEDLINE
- Publication Information: Publication: 2018- : Stuttgart : Thieme
Original Publication: Stuttgart, F.K. Schattauer. - Subject Terms: Circadian Rhythm* ; Sex Characteristics*; Aging/*metabolism ; Parotid Gland/*metabolism ; Sodium Pertechnetate Tc 99m/*metabolism ; Submandibular Gland/*metabolism ; Tomography, Emission-Computed, Single-Photon/*standards; Animals ; Biological Transport ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Parotid Gland/diagnostic imaging ; Reference Values ; Submandibular Gland/diagnostic imaging
- Abstract: Aim: The aim of this study was to establish normal values for parotid gland (PG) and submandibular-sublingual salivary gland complex (SSC) uptake of 99m technetium pertechnetate ( 99m TcO
4 ) as a function of age, sex and circadian rhythm in mice.
Methods: In 12 female (F) and 12 male (M) C57BL/6N mice, nine consecutive SPECT images of 10 min each were acquired as dynamic acquisitions beginning 5 min after intravenous injection of 80 MBq 99m TcO4 . Each mouse was imaged in follow-up studies at 1, 3, 6, 12 and 24 months of age. In order to assess for physiologic changes related to circadian rhythm, animals were imaged during light (sleeping phase) as well as during night conditions (awake phase). The percentage tracer uptake of the injected activity is expressed as median %ID.
Results: Maximum 99m TcO4 uptake occurred earlier in PG at 11 min compared to SSC at 79 min (p < 0.001). No significant effect of circadian rhythm was observed in PG (p = 0.64) and SSC uptake (p = 0.27). With aging, 99m TcO4 uptake significantly decreased for PG (p < 0.001) while it increased for SSC (p < 0.001). F (0.5) had a significantly higher PG uptake than M (0.3; p < 0.001) up to an age of 24 months. However, SSC uptake of F (4.6) was higher than that of M (3.8; p = 0.014) only at the age of 1 month. Thereafter, F (5.6) had lower SSC uptake than M (9.2; p < 0.001) from 3 months onwards. Normalizing %ID to gland volume showed that F had a significantly higher uptake (%ID/mm 3 ) in both PG (F 0.013; M 0.007; p < 0.001) and in SSC (F 0.110; M 0.075; p < 0.001).
Conclusion: Uptake patterns differed among PG and SSC with a significant impact of age and sex while circadian rhythm had no significant influence. Therefore, design of salivary gland studies in mice using 99m TcO4 should consider age and sex as relevant factors.
Competing Interests: The authors declare that they have no conflict of interest.
(© Georg Thieme Verlag KG Stuttgart · New York.) - Contributed Indexing: Local Abstract: [Publisher, German] ZIEL: Ziel dieser Studie war die Erhebung von Normwerten für den 99m Technetium-Pertechnetat ( 99m TcO
4 ) Uptake der Parotis (PG) und des Submandibular-Sublingualen-Speicheldrüsenkomplexes (SSC) in Abhängigkeit von Alter, Geschlecht und circadianem Rhythmus bei der Maus. [Publisher, German] Bei 12 weiblichen (F) und 12 männlichen (M) C57BL/6N Mäusen wurden neun konsekutive SPECT Aufnahmen von jeweils 10 min Dauer 5 min nach intravenöser Injektion von 80 MBq 99m TcO4 durchgeführt. Jede Maus wurde mit 1, 3, 6, 12 und 24 Monaten untersucht. Um Veränderungen auf Grund des circadianen Rhythmus zu erfassen, erfolgte die Untersuchung der Tiere während der Hellphase (Schlafphase) sowie während der Dunkelphase (Wachphase). Der prozentuale Tracer Uptake ist als Median %ID der injizierten Aktivität angegeben. [Publisher, German] Der maximale 99m TcO4 Uptake lag mit 11 min bei der PG früher im Vergleich zum SSC mit 79 min (p < 0,001). Weder PG (p = 0,64) noch SSC (p = 0,27) zeigten einen signifikanten Unterschied in Abhängigkeit vom circadianen Rhythmus.Mit dem Alter fiel der 99m TcO4 Uptake der PG signifikant ab (p < 0,001), während er im SSC (p < 0,001) anstieg. Im Vergleich zu M hatten F bis zu einem Alter von 2 Jahren einen signifikant höheren Uptake der PG (F 0,5; M 0,3; p < 0,001). Dagegen war der SSC-Uptake bei F nur im Alter von 1 Monat höher (F 4,6; M 3,8; p = 0,014). Ab einem Alter von 3 Monaten konnte bei F ein geringerer Uptake im SSC beobachtet werden (F 5,6; M 9,2; p < 0,001). Bei Normierung des %ID auf das Speicheldrüsenvolumen zeigten F einen signifikant höheren Uptake (%ID/mm 3 ) sowohl in der PG (F 0,013; M 0,007; p < 0,001) als auch im SSC (F 0,110; M 0,075; p < 0,001). [Publisher, German] PG und SSC zeigten Unterschiede im Uptake in Abhängigkeit von Alter und Geschlecht, während der circadiane Rhythmus keinen signifikanten Einfluss hatte. Folglich sollten beim Studiendesign mit 99m TcO4 bei Speicheldrüsenuntersuchungen der Maus Alter und Geschlecht als wichtige Einflussfaktoren berücksichtigt werden. - Accession Number: A0730CX801 (Sodium Pertechnetate Tc 99m)
- Publication Date: Date Created: 20190216 Date Completed: 20190222 Latest Revision: 20220331
- Publication Date: 20240628
- Accession Number: 10.1055/a-0810-0174
- Accession Number: 30769372
- Transliterated Title:
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