Evaluation of antioxidant and oxidant status of goats ( Capra aegagrus hircus ) naturally infected with Haemonchus contortus .

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  • Author(s): Rashid S;Rashid S; Irshadullah M; Irshadullah M
  • Source:
    Journal of helminthology [J Helminthol] 2019 Feb 14; Vol. 94, pp. e36. Date of Electronic Publication: 2019 Feb 14.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: London School Of Hygiene And Tropical Medicine Country of Publication: England NLM ID: 2985115R Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2697 (Electronic) Linking ISSN: 0022149X NLM ISO Abbreviation: J Helminthol Subsets: MEDLINE
    • Publication Information:
      Publication: London : London School Of Hygiene And Tropical Medicine
      Original Publication: London [etc.]
    • Subject Terms:
      Antioxidants/*metabolism ; Goat Diseases/*metabolism ; Haemonchiasis/*veterinary ; Haemonchus/*physiology ; Oxidants/*metabolism; Animals ; Catalase/metabolism ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Glutathione Transferase/metabolism ; Goat Diseases/parasitology ; Goats ; Haemonchiasis/metabolism ; Haemonchiasis/parasitology ; Malondialdehyde/metabolism ; Oxidative Stress ; Superoxides/metabolism
    • Abstract:
      The present study aimed to assess the antioxidant and oxidant status of goats naturally infected with Haemonchus contortus. Based upon the parasite burden, infection in goats was categorized as heavy (> 500 worms), mild (100-500 worms) or low (< 100 worms). Abomasal tissues from non-infected and infected goats were used for the determination of catalase (CAT), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), aspartate (AST) and alanine (ALT) aminotransferases, acid (ACP) and alkaline (ALP) phosphatases, superoxide content (O2-), protein carbonyl (PC), malondialdehyde (MDA) and reduced glutathione (GSH). A significantly higher level of CAT, GST and GR activity and a lower level of GPx activity were recorded in infected compared to non-infected tissue. A significant increase in the level of AST, ALT, ALP and ACP was found in the abomasal tissue of the infected animals, which was related to the worm burden. The oxidative stress markers were also altered, with a significant decline in GSH levels, whereas MDA, PC and O2- concentrations showed a marked increase. In conclusion, it has been demonstrated that haemonchosis in goats resulted in considerable oxidative stress, which was directly related to the worm burden.
    • Contributed Indexing:
      Keywords: Antioxidant enzymes; Haemonchus contortus; goats; oxidative stress
    • Accession Number:
      0 (Antioxidants)
      0 (Oxidants)
      11062-77-4 (Superoxides)
      4Y8F71G49Q (Malondialdehyde)
      EC 1.11.1.6 (Catalase)
      EC 1.11.1.9 (Glutathione Peroxidase)
      EC 2.5.1.18 (Glutathione Transferase)
      GAN16C9B8O (Glutathione)
    • Publication Date:
      Date Created: 20190215 Date Completed: 20200130 Latest Revision: 20200130
    • Publication Date:
      20221213
    • Accession Number:
      10.1017/S0022149X19000117
    • Accession Number:
      30761971