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Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register.
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- Author(s): Maple-Brown LJ;Maple-Brown LJ;Maple-Brown LJ; Lindenmayer G; Lindenmayer G; Lindenmayer G; Barzi F; Barzi F; Whitbread C; Whitbread C; Whitbread C; Connors C; Connors C; Moore E; Moore E; Boyle J; Boyle J; Boyle J; Kirkwood M; Kirkwood M; Lee IL; Lee IL; Longmore D; Longmore D; van Dokkum P; van Dokkum P; van Dokkum P; Wicks M; Wicks M; Dowden M; Dowden M; Inglis C; Inglis C; Cotter M; Cotter M; Kirkham R; Kirkham R; Corpus S; Corpus S; Chitturi S; Chitturi S; Thomas S; Thomas S; O'Dea K; O'Dea K; Zimmet P; Zimmet P; Oats J; Oats J; McIntyre HD; McIntyre HD; Brown A; Brown A; Brown A; Shaw JE; Shaw JE
- Source:
Journal of diabetes [J Diabetes] 2019 Sep; Vol. 11 (9), pp. 761-770. Date of Electronic Publication: 2019 Feb 19.- Publication Type:
Journal Article; Observational Study- Language:
English - Source:
- Additional Information
- Corporate Authors:
- Source: Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-0407 (Electronic) Linking ISSN: 17530407 NLM ISO Abbreviation: J Diabetes Subsets: MEDLINE
- Publication Information: Original Publication: Richmond, Vic. : Blackwell Publishing Asia, 2009-
- Subject Terms: Biomarkers/*blood ; Diabetes Mellitus, Type 2/*drug therapy ; Diabetes, Gestational/*drug therapy ; Hypoglycemic Agents/*therapeutic use ; Metformin/*therapeutic use ; Prediabetic State/*drug therapy; Adult ; Australia/epidemiology ; Birth Weight ; Blood Glucose/metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes, Gestational/blood ; Diabetes, Gestational/epidemiology ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Northern Territory ; Population Groups ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Pregnancy ; Pregnancy Outcome ; Prognosis
- Abstract: Background: In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycemia in pregnancy. The prevalence of type 2 diabetes (T2D) in pregnancy is up to 10-fold higher in Indigenous than non-Indigenous Australian mothers, and the use of metformin is common. We assessed birth outcomes in relation to metformin use during pregnancy from a clinical register.
Methods: The study included women with gestational diabetes (GDM), newly diagnosed diabetes in pregnancy (DIP), or pre-existing T2D from 2012 to 2016. Data were analyzed for metformin use in the third trimester. Regression models were adjusted for maternal age, body mass index, parity, and insulin use.
Results: Of 1649 pregnancies, 814 (49.4%) were to Indigenous women, of whom 234 (28.7%) had T2D (vs 4.6% non-Indigenous women; P < 0.001). Metformin use was high in Indigenous women (84%-90% T2D, 42%-48% GDM/DIP) and increased over time in non-Indigenous women (43%-100% T2D, 14%-35% GDM/DIP). Among Indigenous women with GDM/DIP, there were no significant differences between groups with and without metformin in cesarean section (51% vs 39%; adjusted odds ratio [aOR] 1.25, 95% confidence interval [CI] 0.87-1.81), large for gestational age (24% vs 13%; aOR 1.5, 95% CI 0.9-2.5), or serious neonatal adverse events (9.4% vs 5.9%; aOR 1.32, 95% CI 0.68-2.57). Metformin use was independently associated with earlier gestational age (37.7 vs 38.5 weeks), but the risk did not remain independently higher after exclusion of women managed with medical nutrition therapy alone, and the increase in births <37 weeks was not significant on multivariate analysis.
Conclusions: We found no clear evidence of any adverse outcomes related to the use of metformin for the treatment of hyperglycemia in pregnancy.
(© 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.) - References: Minges KE, Zimmet P, Magliano DJ, Dunstan DW, Brown A, Shaw JE. Diabetes prevalence and determinants in Indigenous Australian populations: a systematic review. Diabetes Res Clin Pract. 2011;93:139-149.
Hod M, Kapur A, Sacks DA, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care. Int J Gyneacol Obstet. 2015;131(Suppl 3):S173-S211.
Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991-2002.
Manderson JG, Mullan B, Patterson CC, Hadden DR, Traub AI, McCance DR. Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy. Diabetologia. 2002;45:991-996.
Horvath K, Koch K, Jeitler K, et al. Effects of treatment in women with gestational diabetes mellitus: systematic review and meta-analysis. BMJ. 2010;340:c1395.
Hall J, O'Neil L. Mothers and Babies 2014. Darwin, Australia: Northern Territory Department of Health; 2016.
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP, Mi GTI. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008;358:2003-2015.
Ainuddin JA, Karim N, Zaheer S, Ali SS, Hasan AA. Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy. J Diabetes Res. 2015;2015:325851.
Hoffman L, Nolan C, Wilson JD, Oats JJ, Simmons D. Gestational diabetes mellitus - management guidelines. The Australasian Diabetes in Pregnancy Society. Med J Aust. 1998;169:93-97.
Metzger BE, Gabbe SG, Persson B, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676-682.
World Health Organization (WHO). Diagnostic Criteria and Classification Of Hyperglycaemia First Detected in Pregnancy. Geneva, Switzerland: WHO; 2013.
Kirkham R, Whitbread C, Connors C, et al. Implementation of a diabetes in pregnancy clinical register in a complex setting: findings from a process evaluation. PLoS One. 2017;12:e0179487.
Case A, Zhang X, Dempsey K. Mothers and Babies 2012. Darwin, Australia: Northern Territory Department of Health; 2015.
Hall J, Case A, O'Neil L. Mothers and Babies 2013. Darwin, Australia: Northern Territory Department of Health; 2015.
Dobbins TA, Sullivan EA, Roberts CL, Simpson JM. Australian national birthweight percentiles by sex and gestational age, 1998-2007. Med J Aust. 2012;197:291-294.
Guaran RL, Wein P, Sheedy M, Walstab J, Beischer NA. Update of growth percentiles for infants born in an Australian population. Aust N Z J Obstet Gynaecol. 1994;34:39-50.
Lee I, Purbrick B, Barzi F, et al. Cohort profile: The Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Int J Epidemiol. 2018;47:1045-1046h.
Simmons D, Walters BN, Rowan JA, McIntyre HD. Metformin therapy and diabetes in pregnancy. Med J Aust. 2004;180:462-464.
Hyer S, Balani J, Shehata H. Metformin in pregnancy: mechanisms and clinical applications. Int J Mol Sci. 2018;19:7.
Priya G, Kalra S. Metformin in the management of diabetes during pregnancy and lactation. Drugs Context. 2018;7:212523.
Rowan JA, Rush EC, Plank LD, et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care. 2018;6:e000456.
Simeonova-Krstevska S, Bogoev M, Bogoeva K, et al. Maternal and neonatal outcomes in pregnant women with gestational diabetes mellitus treated with diet, metformin or insulin. Open Access Maced J Med Sci. 2018;6:803-807.
Alqudah A, McKinley MC, McNally R, et al. Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. Diabet Med. 2018;35:160-172.
Nankervis A, Conn J. Gestational diabetes mellitus: negotiating the confusion. Aust Fam Physician. 2013;42:528-531.
National Institute for Heath and Care Excellence (NICE) Diabetes in pregnancy: management from preconception to the postnatal period. Published February 2015. https://www.nice.org.uk/guidance/ng3. Accessed April 1, 2018.
American Diabetes Association. Management of diabetes in pregnancy: standards of medical care in diabetes - 2018. Diabetes Care. 2018;41(Suppl 1):S137-S143.
Remote Primary Health Care Manuals. Minymaku Kutju Tjukurpa - Women's Business Manual. 5th ed. Alice Springs, Australia: Congress Alukura and Nganampa Health Council Inc; 2014.
Langer O. Pharmacological treatment of gestational diabetes mellitus: point/counterpoint. Am J Obstet Gynecol. 2018;218:490-499.
Butalia S, Gutierrez L, Lodha A, Aitken E, Zakariasen A, Donovan L. Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. Diabet Med. 2017;34:27-36.
Corcoy R, Balsells M, Garcia-Patterson A, Shmueli A, Hadar E. Pharmacotherapy for hyperglycemia in pregnancy: do oral agents have a place? Diabetes Res Clin Pract. 2018;145:51-58.
Kirkham R, Boyle JA, Whitbread C, et al. Health service changes to address diabetes in pregnancy in a complex setting: perspectives of health professionals. BMC Health Serv Res. 2017;17:524. - Grant Information: 1032116 Australian National Health and Medical Research Council (NHMRC); 631974 Australian National Health and Medical Research Council (NHMRC); 1092968 Australian National Health and Medical Research Council (NHMRC); 1078477 Australian National Health and Medical Research Council (NHMRC)
- Contributed Indexing: Keywords: birth outcomes; diabetes in pregnancy; gestational diabetes; metformin; type 2 diabetes in pregnancy; 二甲双胍; 出生结果; 妊娠期2型糖尿病; 妊娠期糖尿病; 妊娠糖尿病
Local Abstract: [Publisher, Chinese] 摘要: 背景 在澳大利亚北部地区, 原住民母亲的婴儿出生率占33%, 她们妊娠期间出现高血糖的风险很高。原住民母亲在妊娠期间的2型糖尿病(T2D)患病率与非原住民澳大利亚母亲相比较要高10倍, 并且经常使用二甲双胍治疗。我们利用临床登记表数据评估了妊娠期间使用二甲双胍治疗与出生结果之间的关系。 方法 这项研究从2012至2016年纳入了妊娠糖尿病(gestational diabetes, GDM)、妊娠期新诊断糖尿病(newly diagnosed diabetes in pregnancy, DIP)以及既往已经存在T2D的妇女。对妊娠晚期使用二甲双胍的数据进行了分析。根据母亲年龄、体重指数、产次以及胰岛素使用情况校正了回归模型。 结果 在1649名孕妇中有814名(49.4%)为原住民妇女, 其中234名(28.7%)为T2D(非原住民妇女T2D比例为4.6%;P < 0.001)。原住民妇女的二甲双胍使用率更高(在T2D中为84%-90%, 在GDM/DIP中为42%-48%), 并且在非原住民妇女中随着时间的推移使用率在上升(在T2D中为43%-100%, 在GDM/DIP中为14%-35%)。在合并GDM/DIP的原住民妇女中, 使用二甲双胍治疗组与不使用二甲双胍治疗组之间的剖宫产率(分别为51%与39%; 校正后的odds ratio [aOR]为1.25, 95%置信区间[CI]为0.87-1.81)、出现大胎龄率(分别为24%与13%;aOR为1.5, 95% CI为0.9-2.5)、新生儿出现严重不良事件率(分别为9.4%与5.9%;aOR为1.32, 95% CI为0.68-2.57)都没有显著性差异。使用二甲双胍治疗与胎龄更小(分别为37.7与38.5周)独立相关, 但是将单独接受药物营养治疗的妇女排除之后, 这种风险没有独立地处于较高的水平, 并且多变量分析显示<37周的出生率并没有显著地升高。 结论 我们没有发现任何与妊娠期间高血糖妇女使用二甲双胍治疗出现不良结果相关的明确证据。. - Accession Number: 0 (Biomarkers)
0 (Blood Glucose)
0 (Hypoglycemic Agents)
9100L32L2N (Metformin) - Publication Date: Date Created: 20190126 Date Completed: 20200312 Latest Revision: 20200312
- Publication Date: 20240628
- Accession Number: 10.1111/1753-0407.12905
- Accession Number: 30680949
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