Clarifying pathways to poor psychological health: The mediating role of psychosocial factors in the relationship between general psychopathology and quality of life impairment in patients diagnosed with schizophrenia.

Publisher: Wiley Country of Publication: United States NLM ID: 0217132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4679 (Electronic) Linking ISSN: 00219762 NLM ISO Abbreviation: J Clin Psychol Subsets: MEDLINE

Publication: <2005-> : Hoboken, N.J. : Wiley
Original Publication: Brandon, Vt. [etc.] Clinical Psychology Pub. Co.

Drug-Related Side Effects and Adverse Reactions* ; Psychological Distress* ; Quality of Life*/psychology ; Schizophrenia*/drug therapy ; Schizophrenia*/physiopathology ; Schizophrenic Psychology*; Adult ; Female ; Humans ; Male ; Middle Aged

Objectives: The present study examines the latent factor structure of general psychopathology and investigates the mediating role of unmet psychosocial concerns, motivation, and medication side effects in the relationship between general psychopathology and quality of life (QOL) impairment in patients with schizophrenia.
Methods: A total of 251 patients completed self-report measures of unmet psychosocial concerns, motivation, medication side effects, and physical/mental QOL impairment. The severity of schizophrenia was assessed on the Positive and Negative Syndrome Scale.
Results: Exploratory factor analysis revealed one latent factor (emotional distress) of general psychopathology. Mediation path analyses controlling for confounding variables revealed significant indirect effects of unmet psychosocial concerns, motivation, and medication side effects on emotional distress and physical/mental QOL impairment.
Conclusions: Our findings suggest that identifying optimal methods of managing co-occurring emotional distress as well as secondary psychosocial factors on psychological health may improve QOL among patients diagnosed with schizophrenia.
(© 2019 The Authors. Journal of Clinical Psychology Published by Wiley Periodicals, Inc.)

Neuropsychiatr Dis Treat. 2014 Jan 16;10:97-110. (PMID: 24476630)
Psychol Med. 2012 Jul;42(7):1461-73. (PMID: 22099529)
J Clin Psychol. 2019 Jun;75(6):1022-1033. (PMID: 30671966)
Schizophr Res. 2013 Jan;143(1):38-43. (PMID: 23148897)
Schizophr Bull. 2018 Oct 17;44(6):1195-1203. (PMID: 29762765)
J Clin Epidemiol. 1998 Nov;51(11):903-12. (PMID: 9817107)
Psychiatry Res. 2018 Oct;268:392-399. (PMID: 30125870)
Int J Psychiatry Clin Pract. 2009;13(4):278-84. (PMID: 24916937)
Schizophr Bull. 2007 Sep;33(5):1225-37. (PMID: 17204532)
Schizophr Bull. 2017 Mar 1;43(2):240-244. (PMID: 27421793)
Schizophr Res. 2012 May;137(1-3):246-50. (PMID: 22356801)
Br J Psychiatry. 2000 Jul;177:42-6. (PMID: 10945087)
Br J Psychiatry. 2017 Oct;211(4):198-204. (PMID: 28882827)
Schizophr Bull. 1987;13(2):261-76. (PMID: 3616518)
Qual Life Res. 2008 Feb;17(1):115-22. (PMID: 18030594)
Clin Psychol Rev. 2014 Aug;34(6):482-95. (PMID: 25105273)
PLoS Med. 2005 May;2(5):e141. (PMID: 15916472)
Schizophr Res. 2009 Aug;113(1):27-33. (PMID: 19525092)
Br J Psychiatry. 2013 Apr;202(4):253-60. (PMID: 23549941)
Psychiatry Res. 2015 Aug 30;228(3):724-8. (PMID: 26077848)
Schizophr Res. 2016 Apr;172(1-3):23-8. (PMID: 26947210)
Med Care. 1992 Jun;30(6):473-83. (PMID: 1593914)
Psychiatry Res. 2004 Dec 15;129(2):141-7. (PMID: 15590041)
Schizophr Res. 2014 Apr;154(1-3):83-8. (PMID: 24613000)
Psychiatry Res. 2015 Feb 28;225(3):695-701. (PMID: 25544550)
Acta Psychiatr Scand. 2016 Oct;134(4):360-7. (PMID: 27497263)

Keywords: emotional distress; mediation; psychopathology; quality of life; schizophrenia

Date Created: 20190124 Date Completed: 20200824 Latest Revision: 20210109

20231215

PMC6563093

10.1002/jclp.22747

30671966