Prevention & control of fluorosis & linked disorders: Developments in the 21 st Century - Reaching out to patients in the community & hospital settings for recovery.

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  • Additional Information
    • Source:
      Publisher: Medknow Country of Publication: India NLM ID: 0374701 Publication Model: Print Cited Medium: Internet ISSN: 0971-5916 (Print) Linking ISSN: 09715916 NLM ISO Abbreviation: Indian J Med Res Subsets: MEDLINE
    • Publication Information:
      Publication: <2011- > : Mumbai : Medknow
      Original Publication: New Delhi : Council Of Medical Research
    • Subject Terms:
      Drinking Water*/chemistry ; Drinking Water*/standards ; Fluoride Poisoning*/epidemiology ; Fluoride Poisoning*/etiology ; Fluoride Poisoning*/physiopathology ; Fluoride Poisoning*/prevention & control ; Fluorosis, Dental*/epidemiology ; Fluorosis, Dental*/etiology ; Fluorosis, Dental*/prevention & control; Fluorides/toxicity ; Humans ; India/epidemiology ; Nutritional Sciences/methods ; Prevalence ; Research
    • Abstract:
      The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and adults are discussed. Fluoride toxicity destroys the probiotics in the gut, resulting in vitamin B 12 depletion, an essential ingredient in haemoglobin (Hb) biosynthesis. The article provides an overview of National Technology Mission on Safe Drinking Water and its contributions to fluorosis control. National Programme for Prevention and Control of Fluorosis is presently in operation in India and its focus cited. Major emphasis has been laid on a variety of disorders surfacing in India due to fluoride toxicity/fluorosis as 'fluorosis-linked disorders', viz. anaemia in pregnancy, schoolchildren, thyroid hormone abnormalities, hypertension, iodine deficiency disorders/goitre, renal failure and calcium+vitamin D-resistant rickets in children. The major action taken by the Indian Council of Medical Research (ICMR), Government of India in establishing a Centre of Excellence for Fluorosis Research in India and its contributions are highlighted.
      Competing Interests: None
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    • Contributed Indexing:
      Keywords: Anaemia; diagnosis; hypertension; interventions; recovery; status fluorosis; stillbirth
    • Accession Number:
      0 (Drinking Water)
      Q80VPU408O (Fluorides)
    • Publication Date:
      Date Created: 20190123 Date Completed: 20190613 Latest Revision: 20200225
    • Publication Date:
      20240829
    • Accession Number:
      PMC6366265
    • Accession Number:
      10.4103/ijmr.IJMR_1775_18
    • Accession Number:
      30666981