Effect of topical mometasone furoate on adenoidal lymphoid tissue: a light microscopic study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 8706896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-5460 (Electronic) Linking ISSN: 00222151 NLM ISO Abbreviation: J Laryngol Otol Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge : Cambridge University Press
      Original Publication: London : Headley Brothers,
    • Subject Terms:
      Adenoids/*diagnostic imaging ; Lymphoid Tissue/*pathology ; Microscopy/*methods ; Mometasone Furoate/*administration & dosage ; Nasal Obstruction/*diagnosis; Adenoids/drug effects ; Administration, Topical ; Anti-Inflammatory Agents/administration & dosage ; Child ; Female ; Humans ; Male ; Nasal Obstruction/etiology ; Nasal Sprays ; Pilot Projects ; Prospective Studies
    • Abstract:
      Background: Adenoid hypertrophy is a common cause of upper airway obstruction, and adenoidectomy is one of the most frequently performed operations in children. Topical nasal steroids can act directly on nasopharyngeal lymphoid tissue to decrease its reactive inflammatory changes and potentially reduce its size.
      Objective: To study the light microscopic changes in adenoidal lymphoid tissue after one month of topical steroid use.
      Methods: Twenty-six children with adenoid hypertrophy grade 3 scheduled for adenoidectomy were randomly divided into two equal groups: one group received mometasone furoate aqueous nasal spray (Nasonex) 100 mcg/day for four weeks, and a control group received nasal normal saline 0.9 per cent for four weeks. The removed adenoids were examined histopathologically.
      Results: Adenoidal tissue from the mometasone group had less reactive germinal centres and less spongiosis compared to the control group. The latter showed proliferating, reactive, variable sized and shaped lymphoid follicles, with congested blood vessels in the interfollicular areas.
      Conclusion: The use of intranasal mometasone furoate aqueous nasal spray (Nasonex) for one month reduced adenoidal tissue reactive cellular changes and its vascularity. This is, however, a pilot study; a longer treatment period is needed to assess the effect of treatment on adenoidal size.
    • Contributed Indexing:
      Keywords: Adenoids; Microscopy; Mometasone; Pathology
    • Accession Number:
      0 (Anti-Inflammatory Agents)
      0 (Nasal Sprays)
      04201GDN4R (Mometasone Furoate)
    • Publication Date:
      Date Created: 20190109 Date Completed: 20190403 Latest Revision: 20190403
    • Publication Date:
      20221213
    • Accession Number:
      10.1017/S0022215118002268
    • Accession Number:
      30616699