Non-traditional risk factors for coronary calcification and its progression in patients with type 2 diabetes: The impact of postprandial glycemia and fetuin-A.

Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE

Publication: Nov. 2012- : London : Sage Publications
Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.

Biomarkers/*metabolism ; Calcinosis/*etiology ; Coronary Artery Disease/*etiology ; Diabetes Mellitus, Type 2/*complications ; Hyperglycemia/*physiopathology ; Hypoglycemia/*physiopathology ; alpha-2-HS-Glycoprotein/*metabolism; Blood Glucose ; Calcinosis/metabolism ; Calcinosis/pathology ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/pathology ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Postprandial Period ; Prognosis ; Prospective Studies ; Risk Factors

Objective: This study was performed to assess the impact of risk factors on the presence and progression of coronary calcification in patients with type 2 diabetes.
Methods: We prospectively enrolled 45 patients without cardiovascular or kidney disease. Coronary calcification was measured with multidetector computed tomography at baseline and 18 months. We also measured blood pressure; body mass index; serum levels of calcium, phosphate, and 25-hydroxyvitamin D; mineral bone density; and levels of alkaline phosphatase, parathormone, fetuin-A, high-sensitivity C-reactive protein, fibrinogen, albumin, homocysteine, lipids, HbA1c, and average preprandial and postprandial blood glucose at 18 months. Information about severe hypoglycemia and smoking was recorded. Spearman's correlation coefficients were calculated. Multiple linear regression was used for the multivariate analysis.
Results: The median baseline calcium score was 63, and that at 18 months was 100. In the univariate analysis, albumin was significantly correlated with the baseline calcium score. Fetuin-A and postprandial glycemia were correlated with calcium score progression. In the multivariate model, postprandial glycemia and fetuin-A were independently associated with calcium score progression.
Conclusions: Fetuin-A and postprandial glycemia influence coronary calcification progression in patients with type 2 diabetes. The absence of some correlations could be due to pharmacological treatments for cardiovascular risk reduction.

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Keywords: (non-traditional/new) risk factors; Diabetes mellitus; coronary calcification; fetuin-A; hyperglycemia; postprandial; type 2

0 (AHSG protein, human)
0 (Biomarkers)
0 (Blood Glucose)
0 (alpha-2-HS-Glycoprotein)

Date Created: 20190109 Date Completed: 20190611 Latest Revision: 20200225

20221213

PMC6381483

10.1177/0300060518814080

30616461