The association between an anxiety disorder and cancer in medical history.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
    • Subject Terms:
      Anxiety Disorders/*psychology ; Cancer Survivors/*psychology ; Neoplasms/*psychology; Aged ; Comorbidity ; Cross-Sectional Studies ; Depressive Disorder/psychology ; Female ; Humans ; Male ; Medical History Taking ; Middle Aged ; Patient Health Questionnaire ; Surveys and Questionnaires
    • Abstract:
      Background: Cancer patients can feel depression and anxiety any time after a cancer diagnosis. The Generalized Anxiety Disorder Scale (GAD-7) is an instrument for the assessment of anxiety. The main objective of this work was to compare general anxiety levels between cancer survivors and individuals without a history of cancer in a population-based study (LIFE-ADULT) with 10,000 participants.
      Methods: All participants (18-80 years) completed the GAD-7 and other psychological and medical questionnaires. A score of 10 or greater for GAD-7 (of total 21) indicates a probable generalized anxiety disorder.
      Results: 954 participants reported a diagnosis of cancer in their medical history. In the multivariate analysis an anxiety disorder was associated with prior cancer diagnosis (OR: 1.8; 95% CI [1.4-2.4]), age -every additional year- (OR: 0.983; [0.976-0.991]), female gender (OR: 1.8; [1.5-2.2]) and low socioeconomic status (OR: 2.0; [1.7-2.5]) all p < 0.001. There were no significant associations between general anxiety and other comorbidities, such as myocardial infarction (OR: 1.0; p = 0.948), stroke (OR: 1.4; p = 0.237) or diabetes (OR: 1.0; p = 0.326). There was also no significant difference in anxiety disorder among cancer survivors regarding the time passed since the initial cancer diagnosis (OR: 1.1; [0.6-1.9], p = 0.804 comparing 5-10 years after a diagnosis of cancer vs. ≤5 years and OR: 0.6; [0.4-1.1], p = 0.107 comparing >10 vs. ≤5 years).
      Limitations: This study has a cross-sectional character, therefore, causal conclusions cannot be drawn.
      Conclusion: Cancer survivors may require screening for anxiety disorders and long-term professional psychosocial support.
      (Copyright © 2018 Elsevier B.V. All rights reserved.)
    • Publication Date:
      Date Created: 20190106 Date Completed: 20190401 Latest Revision: 20190401
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jad.2018.12.019
    • Accession Number:
      30611061