Maternal and neonatal screening methods for congenital cytomegalovirus infection.

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  • Author(s): Tanimura K;Tanimura K; Yamada H; Yamada H
  • Source:
    The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2019 Mar; Vol. 45 (3), pp. 514-521. Date of Electronic Publication: 2018 Dec 27.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Country of Publication: Australia NLM ID: 9612761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0756 (Electronic) Linking ISSN: 13418076 NLM ISO Abbreviation: J Obstet Gynaecol Res Subsets: MEDLINE
    • Publication Information:
      Publication: [Melbourne, Vic. : Wiley on behalf of the Japan Society of Obstetrics and Gynecology]
      Original Publication: Tokyo : University of Tokyo Press, c1996-
    • Subject Terms:
      Infectious Disease Transmission, Vertical*; Cytomegalovirus Infections/*congenital ; Cytomegalovirus Infections/*diagnosis ; Neonatal Screening/*methods; Amniotic Fluid/virology ; Cytomegalovirus/isolation & purification ; Female ; Humans ; Infant, Newborn ; Prospective Studies
    • Abstract:
      Human cytomegalovirus (CMV) is a common cause of congenital infection that may lead to severe long-term sequelae. Because there are no established vaccines, fetal interventions or neonatal treatments, neither maternal nor neonatal screening is recommended. However, recent studies have indicated that early antiviral treatment may improve neurological outcomes in symptomatic infants with congenital infection. Therefore, prenatal detection may be important in newborns at high risk of such infection. Polymerase chain reaction for CMV DNA in the amniotic fluid is considered the gold standard for diagnosis of intrauterine infection, but its use is limited because amniocentesis is an invasive procedure. In a prospective cohort study, we have reported that the presence of CMV DNA in secretions of the maternal uterine cervix were predictive of congenital infection in groups at high risk. However, we also recently demonstrated that maternal serological screening for primary CMV infection using specific immunoglobulin G, the immunoglobulin G avidity index or specific immunoglobulin M can overlook many cases. Previous research has indicated that the combination of early detection by universal neonatal screening of urinary CMV DNA combined with early antiviral therapy can improve outcomes in infants with symptomatic congenital infection. In this article, we review the current state of maternal and neonatal screening for congenital CMV infection.
      (© 2018 Japan Society of Obstetrics and Gynecology.)
    • Contributed Indexing:
      Keywords: congenital infection; cytomegalovirus; polymerase chain reaction; screening; serological test
    • Publication Date:
      Date Created: 20181228 Date Completed: 20190620 Latest Revision: 20190620
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/jog.13889
    • Accession Number:
      30590863