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Presence of CD34 + in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patients.
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- Author(s): Duarte FB;Duarte FB; DE Jesus Dos Santos TE; DE Jesus Dos Santos TE; Barbosa MC; Barbosa MC; Moura ATG; Moura ATG; DE Vasconcelos JPL; DE Vasconcelos JPL; Rocha-Filho FD; Rocha-Filho FD; Coutinho DF; Coutinho DF; Zalcberg I; Zalcberg I; Vasconcelos PRL; Vasconcelos PRL; Garcia YDO; Garcia YDO; Lemes RPG; Lemes RPG
- Source:
In vivo (Athens, Greece) [In Vivo] 2019 Jan-Feb; Vol. 33 (1), pp. 277-280.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet ISSN: 1791-7549 (Electronic) Linking ISSN: 0258851X NLM ISO Abbreviation: In Vivo Subsets: MEDLINE
- Publication Information: Publication: <2000- > : Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens : Dr. J.G. Delinassios - Subject Terms: Prognosis*; Antigens, CD34/*genetics ; Myelodysplastic Syndromes/*genetics ; Tumor Suppressor Protein p53/*genetics; Adult ; Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; Middle Aged ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Risk Assessment ; Risk Factors
- Abstract: Background/aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a "favorable" prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients.
Materials and Methods: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk.
Results: CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281).
Conclusion: The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patients.
(Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) - References: Haematologica. 2000 Oct;85(10):1117-8. (PMID: 11025619)
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Blood. 2017 May 18;129(20):2818. (PMID: 28522465) - Contributed Indexing: Keywords: CD34 on megakaryocytes; Myelodysplastic syndromes; low risk; p53 protein expression; prognosis
- Accession Number: 0 (Antigens, CD34)
0 (TP53 protein, human)
0 (Tumor Suppressor Protein p53) - Publication Date: Date Created: 20181228 Date Completed: 20190404 Latest Revision: 20200225
- Publication Date: 20240628
- Accession Number: PMC6364072
- Accession Number: 10.21873/invivo.11472
- Accession Number: 30587636
- Source:
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