The Participation of Regulatory Lipids in Vacuole Homotypic Fusion.

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  • Author(s): Starr ML;Starr ML; Fratti RA; Fratti RA; Fratti RA
  • Source:
    Trends in biochemical sciences [Trends Biochem Sci] 2019 Jun; Vol. 44 (6), pp. 546-554. Date of Electronic Publication: 2018 Dec 23.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0968-0004 (Print) Linking ISSN: 09680004 NLM ISO Abbreviation: Trends Biochem Sci Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge (Eng) : Elsevier Trends Journals
      Original Publication: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co.
    • Subject Terms:
      Cholesterol/*metabolism ; Ergosterol/*metabolism ; Glycerides/*metabolism ; Phosphatidic Acids/*metabolism ; Phosphatidylinositols/*metabolism ; Vacuoles/*metabolism; Cholesterol/chemistry ; Ergosterol/chemistry ; Glycerides/chemistry ; Humans ; Membrane Fusion ; Phosphatidic Acids/chemistry ; Phosphatidylinositols/chemistry ; Vacuoles/chemistry
    • Abstract:
      In eukaryotes, organelles and vesicles modulate their contents and identities through highly regulated membrane fusion events. Membrane trafficking and fusion are carried out through a series of stages that lead to the formation of SNARE complexes between cellular compartment membranes to trigger fusion. Although the protein catalysts of membrane fusion are well characterized, their response to their surrounding microenvironment, provided by the lipid composition of the membrane, remains to be fully understood. Membranes are composed of bulk lipids (e.g., phosphatidylcholine), as well as regulatory lipids that undergo constant modifications by kinases, phosphatases, and lipases. These lipids include phosphoinositides, diacylglycerol, phosphatidic acid, and cholesterol/ergosterol. Here we describe the roles of these lipids throughout the stages of yeast vacuole homotypic fusion.
      (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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    • Grant Information:
      R01 GM101132 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: Dgk1; Diacylglycerol; Lipin1; Pah1; Sec18; phosphatidic acid
    • Accession Number:
      0 (Glycerides)
      0 (Phosphatidic Acids)
      0 (Phosphatidylinositols)
      97C5T2UQ7J (Cholesterol)
      Z30RAY509F (Ergosterol)
    • Publication Date:
      Date Created: 20181228 Date Completed: 20191206 Latest Revision: 20200601
    • Publication Date:
      20221213
    • Accession Number:
      PMC6814398
    • Accession Number:
      10.1016/j.tibs.2018.12.003
    • Accession Number:
      30587414