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Toenail manganese as biomarker of drinking water exposure: a reliability study from a US pregnancy cohort.
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- Author(s): Signes-Pastor AJ;Signes-Pastor AJ; Bouchard MF; Bouchard MF; Bouchard MF; Baker E; Baker E; Jackson BP; Jackson BP; Karagas MR; Karagas MR
- Source:
Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2019 Sep; Vol. 29 (5), pp. 648-654. Date of Electronic Publication: 2018 Dec 18.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
- Publication Information: Original Publication: New York, NY : Nature Pub. Group, c2006-
- Subject Terms:
- Abstract: Manganese (Mn) is an essential nutrient; however, overexposure can be neurotoxic. Recent evidence suggests that exposure to Mn from drinking water could be neurotoxic; however, research is hampered by the lack of consensus on a reliable biomarker of Mn exposure. Naturally high concentrations of Mn can occur in groundwater, particularly for private, unregulated water systems. This study aimed to investigate the association between exposure to Mn from drinking water with a relatively low Mn content (median of 2.9 μg/L; range, undetectable-8,340 μg/L) and Mn in toenails from women collected at two time points: during and after pregnancy. Mn concentrations in the paired toenail samples gathered during the second to third trimester of pregnancy and 2 weeks postpartum were correlated (r = 0.47, p < 0.001, n = 596). Among women consuming drinking water Mn in the highest tertile (i.e., > 9.8 μg/L) significant positive correlations were found between water Mn and toenails Mn (r = 0.31 and r = 0.38, for toenail samples collected during pregnancy and postpartum, respectively), whereas little to no correlation was observed at lower water concentrations. Overall, our data suggest that maternal toenail samples are a reliable environmental Mn exposure biomarker and reflect exposure from drinking water.
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Toxicology. 2012 Jan 27;291(1-3):73-82. (PMID: 22085607) - Grant Information: P01 ES022832 United States ES NIEHS NIH HHS; P20 GM104416 United States GM NIGMS NIH HHS; P42 ES007373 United States ES NIEHS NIH HHS; UH3 OD023275 United States OD NIH HHS
- Contributed Indexing: Keywords: Biomarker; Drinking water; Manganese; Toenails
- Accession Number: 0 (Biomarkers)
0 (Drinking Water)
42Z2K6ZL8P (Manganese) - Publication Date: Date Created: 20181220 Date Completed: 20200619 Latest Revision: 20210109
- Publication Date: 20240628
- Accession Number: PMC6581634
- Accession Number: 10.1038/s41370-018-0108-z
- Accession Number: 30563963
- Source:
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