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Progression from acute to chronic hepatitis B is more common in older adults.
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- Author(s): McKeating C;McKeating C; Cadden I; Cadden I; McDougall N; McDougall N; Jessop L; Jessop L; Quah S; Quah S; Lavelle M; Lavelle M; Griffths A; Griffths A; McCaughey C; McCaughey C
- Source:
The Ulster medical journal [Ulster Med J] 2018 Oct; Vol. 87 (3), pp. 177-180. Date of Electronic Publication: 2018 Oct 01.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Ulster Medical Society Country of Publication: Northern Ireland NLM ID: 0417367 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-4207 (Electronic) Linking ISSN: 00416193 NLM ISO Abbreviation: Ulster Med J Subsets: MEDLINE
- Publication Information: Publication: Belfast : Ulster Medical Society
Original Publication: Belfast. - Subject Terms: Disease Progression* ; Hepatitis B*/complications ; Hepatitis B*/epidemiology ; Hepatitis B, Chronic*; Acute Disease ; Adolescent ; Adult ; Age Factors ; Aged ; Female ; HIV Seropositivity/complications ; Hepatitis B Antibodies/analysis ; Hepatitis B Surface Antigens/analysis ; Humans ; Immunoglobulin M/analysis ; Incidence ; Male ; Middle Aged ; Northern Ireland/epidemiology ; Young Adult
- Abstract: Purpose: The rate of progression of acute Hepatitis B (HBV) to chronic disease is quoted as <10%. The purpose of this study was to determine the rate of progression from acute to chronic HBV in Northern Ireland (NI), assessing the influence of age, gender and biochemical parameters.
Methods: All "acute" HBV cases diagnosed in NI between 2011 and 2015 were reviewed. Inclusion criteria: 1). positive HBsAg and positive HBV core IgM; 2). in the absence of positive HBV core IgM, positive HBsAg with a recent negative HBsAg. Patient age, HBsAg, HBV core IgM, peak bilirubin and peak ALT were recorded, along with date and result of repeat HbsAg testing. Mann-Whitney U test was used to compare mean age, peak ALT and bilirubin between clearing and non-clearing groups. Fisher's exact test was used to compare progression to chronicity according to gender and age less than or greater than 50yrs.
Results: Of 80 identified cases, 4 incorrectly categorised cases were excluded. Of the remaining 76, (15 female (mean age 37.27yr), 61 male (mean age 47.39yr)) follow-up data was available for 71 patients (15 female (mean age 37.27yr), 56 male (48.59yr)). All female patients cleared HBV. 42 of 61 males cleared HBV (p=0.0313).Overall the chronicity rate was 18.42% The mean age of those clearing the virus was 43.88 years, versus 55.64 years for those going on to develop chronic HBV (Mann-Whitney U test, z= -2.68, p=0.0037). Clearance rate was 83.72% in patients aged <50yrs and 63.64% in patients 50yrs (p=0.0068).Mean peak ALT (U/L) and peak bilirubin ( ยต mol/L) for the clearing group were 2130 and 174 respectively compared to 656 and 100 for the non-clearing group (z= -3.51, p=0.0002, z= -2.35, p=0.009).
Conclusion: Our results suggest a higher than expected rate of progression from acute to chronic HBV with a significantly higher risk for those over 50yrs. This suggests a need to revise information provided to older patients with acute HBV regarding the likelihood of progression.
Competing Interests: Provenance: externally peer-reviewed. - References: Hepatology. 2007 Feb;45(2):507-39. (PMID: 17256718)
Gut. 2008 Dec;57(12):1713-20. (PMID: 18755887)
J Infect Dis. 1991 May;163(5):1138-40. (PMID: 2019762)
Gastroenterology. 2010 Aug;139(2):474-82. (PMID: 20434450)
J Infect Dis. 2010 Jul 15;202(2):192-201. (PMID: 20533878)
Clin Liver Dis. 2010 Aug;14(3):505-20. (PMID: 20638028)
Hepatol Res. 2016 Jan;46(1):22-8. (PMID: 25651806)
J Gerontol. 1985 Jul;40(4):415-8. (PMID: 4008876)
Clin Infect Dis. 1995 Apr;20(4):992-1000. (PMID: 7795104)
Hepatology. 1993 Oct;18(4):768-74. (PMID: 8406349) - Contributed Indexing: Keywords: Acute; Chronic; HBV; Hepatitis; Northern Ireland; Progression
- Accession Number: 0 (Hepatitis B Antibodies)
0 (Hepatitis B Surface Antigens)
0 (Immunoglobulin M) - Publication Date: Date Created: 20181219 Date Completed: 20190211 Latest Revision: 20200225
- Publication Date: 20240829
- Accession Number: PMC6169415
- Accession Number: 30559541
- Source:
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