Does diabetes decrease the risk of glioma? A systematic review and meta-analysis of observational studies.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 9100013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2585 (Electronic) Linking ISSN: 10472797 NLM ISO Abbreviation: Ann Epidemiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Elsevier, c1990-
    • Subject Terms:
      Observational Studies as Topic*; Brain Neoplasms/*etiology ; Diabetes Mellitus, Type 1/*complications ; Diabetes Mellitus, Type 2/*complications ; Glioma/*etiology; Brain Neoplasms/epidemiology ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Glioma/epidemiology ; Humans ; Male ; Risk Factors
    • Abstract:
      Purpose: Increasing epidemiologic evidence suggests that diabetes mellitus (DM) may be associated with a decreased risk of glioma. This systematic review assessed whether DM was associated with glioma risk.
      Methods: Electronic searches were performed in PubMed, Web of Science, EMBASE, and Cochrane Library databases up to August 30, 2018. A random-effects model was performed to calculate summary effect size with corresponding 95% confidence intervals (CIs).
      Results: In total, 10 studies (eight case-control studies and two cohort studies) matched the inclusion criteria. Meta-analyses of case-control studies showed that DM decreased the risk of glioma by 23% (odds ratio: 0.77, 95% CI: 0.61-0.96; P = .02, I 2  = 82.0%). However, no such effect was observed in cohort studies (relative risk: 0.71, 95% CI: 0.10-4.80; P = .72, I 2  = 61.6%). In the subgroup analyses, DM was associated with a decreased risk of glioma in Caucasians but not in Asians; the inverse association was slightly higher in males than in females.
      Conclusions: Our results indicate that DM decreases the risk of glioma, but the inverse association may vary in subgroups. The present conclusions should be confirmed with further studies.
      (Copyright © 2018 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Diabetes mellitus; Glioblastoma; Glioma; Meta-analysis; Risk
    • Publication Date:
      Date Created: 20181215 Date Completed: 20191028 Latest Revision: 20191028
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.annepidem.2018.11.010
    • Accession Number:
      30545764