Culture-positive shigellosis cases are epidemiologically different to culture-negative/PCR-positive cases.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 9611095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-6405 (Electronic) Linking ISSN: 13260200 NLM ISO Abbreviation: Aust N Z J Public Health Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : [New York] : Elsevier
      Original Publication: Canberra, ACT : Public Health Association of Australia, [1996-
    • Subject Terms:
      Cell Culture Techniques/*methods ; Dysentery, Bacillary/*diagnosis ; Dysentery, Bacillary/*epidemiology ; Polymerase Chain Reaction/*methods ; Shigella/*isolation & purification; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Negative Results ; New South Wales/epidemiology ; Prevalence
    • Abstract:
      Objective: To review the epidemiological differences between culture-positive and culture-negative (but ipaH PCR-positive) cases of shigellosis in Sydney Local Health District (SLHD), NSW, to inform whether changes to the national case definition for shigellosis are required.
      Methods: An audit of all cases of shigellosis (culture-positive vs. culture-negative/PCR-positive) in SLHD from 1 January 2013 to 30 June 2015 was conducted and demographic, clinical and risk factors were analysed and compared between these groups.
      Results: Of the 148 shigellosis cases notified to SLHD, 122 cases (85 culture-positive vs. 37 culture-negative) were included for analysis. Culture-positive cases were more likely than culture-negative/PCR-positive cases to have experienced at least three symptoms (OR 3.18, 95%CI 1.3-7.5), been hospitalised (OR 4.2, 95%CI 1.4-13.2), and have had men-who-have-sex-with-men exposure identified as the source of their infection (OR 28.7, 95%CI 6.2-132.6).
      Conclusions: This study has identified that culture-positive vs. culture-negative/PCR-positive shigellosis cases in NSW differ by clinical severity and risk factors for infection. Implications for public health: The study findings warrant further research to determine the true diagnostic prevalence of Shigella in the culture-negative/PCR-positive group in the Australian context, in order to inform further changes to the national case definition for shigellosis.
      (© 2018 Sydney Local Health District.)
    • Contributed Indexing:
      Keywords: case definition; epidemiology; infectious diseases; shigellosis; surveillance
    • Publication Date:
      Date Created: 20181206 Date Completed: 20190610 Latest Revision: 20190613
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/1753-6405.12844
    • Accession Number:
      30516310