Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0400763 Publication Model: Print Cited Medium: Print ISSN: 0027-5107 (Print) Linking ISSN: 00275107 NLM ISO Abbreviation: Mutat Res Subsets: MEDLINE

Original Publication: Amsterdam : Elsevier, [1964-

Butanones/*pharmacology ; Cyclohexanes/*pharmacology ; Cyclohexanones/*pharmacology ; Ketones/*pharmacology ; Methyl n-Butyl Ketone/*pharmacology ; Mutagens/*pharmacology; Animals ; Cell Transformation, Neoplastic ; Cells, Cultured ; DNA Replication/drug effects ; Female ; Liver/drug effects ; Liver/metabolism ; Lymphoma/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Microsomes, Liver/metabolism ; Mutagenicity Tests/methods ; Salmonella typhimurium/drug effects ; Solvents

3 ketone solvents (methyl ethyl ketone (MEK), methyl isobutyl ketone (MiBK), and isophorone) were tested for potential genotoxicity. The assays of MEK and MiBK included the Salmonella/microsome (Ames) assay, L5178Y/TK+/- mouse lymphoma (ML) assay, BALB/3T3 cell transformation (CT) assay, unscheduled DNA synthesis (UDS) assay, and micronucleus (MN) assay. Only the ML, UDS, and MN assays were conducted on samples of isophorone. No genotoxicity was found for MEK or isophorone. The presence of a marginal response only at the highest, cytotoxic concentration tested in the ML assay, the lack of reproducibility in the CT assay, and clearly negative results in the Ames assay, UDS and MN assays, suggest that MiBK is unlikely to be genotoxic in mammalian systems.

0 (Butanones)
0 (Cyclohexanes)
0 (Cyclohexanones)
0 (Ketones)
0 (Mutagens)
0 (Solvents)
2BR99VR6WA (isophorone)
6PT9KLV9IO (methylethyl ketone)
6QDY60NH6N (Methyl n-Butyl Ketone)
U5T7B88CNP (methyl isobutyl ketone)

Date Created: 19881001 Date Completed: 19881118 Latest Revision: 20190702

20231215

10.1016/0165-1218(88)90154-1

3050497