Population-based birth defects data in the United States, 2011-2015: A focus on eye and ear defects.

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  • Additional Information
    • Corporate Authors:
      National Birth Defects Prevention Network
    • Source:
      Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101701004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-1727 (Electronic) NLM ISO Abbreviation: Birth Defects Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, N.J. : John Wiley & Sons, Inc.
    • Subject Terms:
      Anophthalmos/*epidemiology ; Congenital Microtia/*epidemiology ; Microphthalmos/*epidemiology; Adult ; Case-Control Studies ; Cataract/epidemiology ; Congenital Abnormalities/epidemiology ; Ear/abnormalities ; Eye Abnormalities ; Female ; Humans ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Maternal Age ; Mothers ; Odds Ratio ; Population Surveillance/methods ; Pregnancy ; Prevalence ; Registries ; Risk Factors ; United States
    • Abstract:
      Background/objectives: In this data brief, we examine major eye and ear anomalies (anophthalmia/microphthalmia, anotia/microtia, and congenital cataract) for a recent 5-year birth cohort using data from 30 population-based birth defects surveillance programs in the United States.
      Methods: As a special call for data for the 2018 NBDPN Annual Report, state programs reported expanded data on eye/ear anomalies for birth years 2011-2015. We calculated the combined overall prevalence (per 10,000 live births) and 95% confidence intervals (CI), for the three anomalies as well as by maternal age, maternal race/ethnicity, infant sex, laterality, presence/absence of other major birth defects, and case ascertainment methodology utilized by the program (active vs. passive).
      Results: The overall prevalence estimate (per 10,000 live births) was 1.5 (95% CI: 1.4-1.5) for anophthalmia/microphthalmia, 1.5 (95% CI: 1.4-1.6) for congenital cataract, and 1.8 (95% CI: 1.7-1.8) for anotia/microtia. Congenital cataract prevalence varied little by maternal race/ethnicity, infant sex, or case ascertainment methodology; prevalence differences were more apparent across strata for anophthalmia/microphthalmia and anotia/microtia. Prevalence among active vs. passive ascertainment programs was 50% higher for anophthalmia/microphthalmia (1.9 vs. 1.2) and two-fold higher for anotia/microtia (2.6 vs. 1.2). Anophthalmia/microphthalmia was more likely than other conditions to co-occur with other birth defects. All conditions were more frequent among older mothers (40+ years).
      Conclusions: This data brief provides recent prevalence estimates for anophthalmia/microphthalmia, congenital cataract, and anotia/microtia that address a data gap by examining pooled data from 30 population-based surveillance systems, covering a five-year birth cohort of about 12.4 million births.
      (© 2018 Wiley Periodicals, Inc.)
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    • Grant Information:
      CC999999 United States ImCDC Intramural CDC HHS; P30 ES005605 United States ES NIEHS NIH HHS; U01 DD001035 United States DD NCBDD CDC HHS; U01 DD001223 United States DD NCBDD CDC HHS
    • Contributed Indexing:
      Keywords: anophthalmia; anotia; birth defects; cataract; congenital; microphthalmia; microtia; population-based surveillance
    • Publication Date:
      Date Created: 20181117 Date Completed: 20190701 Latest Revision: 20210109
    • Publication Date:
      20240829
    • Accession Number:
      PMC6705119
    • Accession Number:
      10.1002/bdr2.1413
    • Accession Number:
      30444307