Betatrophin for diagnosis and prognosis of mothers with gestational diabetes mellitus.

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  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
    • Publication Information:
      Publication: Nov. 2012- : London : Sage Publications
      Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.
    • Subject Terms:
      Angiopoietin-like Proteins/*metabolism ; Biomarkers/*metabolism ; Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*diagnosis ; Diabetes, Gestational/*diagnosis ; Peptide Hormones/*metabolism; Adult ; Angiopoietin-Like Protein 8 ; Case-Control Studies ; Diabetes Mellitus, Type 2/metabolism ; Diabetes, Gestational/metabolism ; Female ; Follow-Up Studies ; Glucose Tolerance Test ; Humans ; Insulin Resistance ; Mothers ; Pregnancy ; Prognosis
    • Abstract:
      Objectives: Betatrophin is a widely used diagnostic marker for type 2 diabetes mellitus (DM), but its clinical utility in diagnosing gestational DM (GDM) is unclear. We evaluated the relationship between betatrophin and the risk of GDM as well as the ability of betatrophin to predict postpartum type 2 DM (PDM).
      Methods: In total, 386 patients were categorized into those with and without PDM. All underwent the oral glucose tolerance test while pregnant. Betatrophin was assessed to examine the diagnostic characteristics of GDM.
      Results: The betatrophin concentration was remarkably higher in patients with than without GDM. The patients were categorized into three groups; those with a betatrophin concentration of 300 to 600 pg/mL and >600 pg/mL had a higher risk of GDM after adjusting for body mass index, age, homeostatic model assessment-insulin resistance (HOMA-IR) concentration, and betatrophin concentration than those with a betatrophin concentration of <300 pg/mL. The HOMA-IR concentration tended to increase as the betatrophin concentration increased, and betatrophin was independently associated with GDM after adjusting for confounders. The betatrophin concentration was higher among pregnant patients with than without PDM.
      Conclusions: Betatrophin has high sensitivity but low specificity for diagnosing GDM and may be a promising predictor of PDM.
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    • Contributed Indexing:
      Keywords: Gestational diabetes mellitus; betatrophin; biomarker; homeostatic model assessment–insulin resistance; postpartum diabetes mellitus; prognosis
    • Accession Number:
      0 (ANGPTL8 protein, human)
      0 (Angiopoietin-Like Protein 8)
      0 (Angiopoietin-like Proteins)
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Peptide Hormones)
    • Publication Date:
      Date Created: 20181106 Date Completed: 20190611 Latest Revision: 20220410
    • Publication Date:
      20221213
    • Accession Number:
      PMC6381505
    • Accession Number:
      10.1177/0300060518808683
    • Accession Number:
      30392425