High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      High-Intensity Interval Training*; Diabetes Mellitus, Type 2/*therapy ; Diabetic Angiopathies/*prevention & control ; Exercise Therapy/*methods ; Myocardium/*metabolism ; Oxygen Consumption/*physiology; Aged ; Combined Modality Therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Angiopathies/metabolism ; Diet ; Female ; Humans ; Male ; Metformin/therapeutic use ; Middle Aged ; Myocardium/pathology
    • Abstract:
      Aim: The present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.
      Methods: Twenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60 min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.
      Results: At baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.3 ± 6.1 vs. 21.7 ± 5.5 ml/kg/min, p = 0.21), and peak exercise heart rate (156.3 ± 15.0 vs. 153.8 ± 12.5 beats/min, p = 0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 ± 2.4 vs. 15.2 ± 2.2 ml/min/kg, p = 0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 ± 2.7-12.8 ± 3.6 L/min, p = 0.03), but not in the control group (15.7 ± 4.9-16.3 ± 4.1 L/min, p = 0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p = 0.03) and heart rate by 9% (p = 0.04).
      Conclusion: Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.
      Trial Registration: ISRCTN78698481. Registered 23 January 2013, retrospectively registered.
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    • Grant Information:
      MR/L016354/1 United Kingdom MRC_ Medical Research Council; SRF-2011-04-017 United Kingdom DH_ Department of Health; L016354 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Keywords: Cardiac function; HIIT; Submaximal exercise; Type 2 diabetes
    • Accession Number:
      9100L32L2N (Metformin)
    • Publication Date:
      Date Created: 20181103 Date Completed: 20190415 Latest Revision: 20210109
    • Publication Date:
      20221213
    • Accession Number:
      PMC6394729
    • Accession Number:
      10.1007/s00592-018-1245-5
    • Accession Number:
      30387015