[New potential of MTHFR gene variations application as an individual sensitivity marker in evaluation of occupational risk of arterial hypertension under exposure to nose].

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  • Additional Information
    • Source:
      Publisher: Redkollegiia Zhurnala Country of Publication: Russia (Federation) NLM ID: 9434213 Publication Model: Print Cited Medium: Print ISSN: 1026-9428 (Print) Linking ISSN: 10269428 NLM ISO Abbreviation: Med Tr Prom Ekol Subsets: MEDLINE
    • Publication Information:
      Publication: Moskva : Redkollegiia Zhurnala
      Original Publication: Moskva : Redkollegiia zhurnala, 1993-
    • Subject Terms:
      Genetic Predisposition to Disease* ; Genetic Variation*; Hypertension/*genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/*genetics ; Noise, Occupational/*adverse effects ; Occupational Diseases/*genetics; Adult ; Case-Control Studies ; Female ; Humans ; Hypertension/epidemiology ; Male ; Mining ; Occupational Diseases/epidemiology ; Occupational Health/standards ; Russia
    • Abstract:
      The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between occupational exposure to noise over 83 dB and hypertension and its predictors - increased activity of serum lipoprotein and homocystein. The studies determined an indicator of the workers' increased sensitivity to arterial hypertension development and to changes in parameters of disordered vascular tone regulation (increased activity of serum lipoprotein and homocystein) under exposure to noise - CT genotype of MTHFR gene. Workers with CT genotype of MTHFR gene, according to epidemiologic analysis, demonstrated increase in relative risk of vascular tone regulation disorders (hypertension predictor). Additional probability ofvascular tone regulation disorders under exposure to noise of 83 dB in sylvinitedressing workers with increased individual sensitivity is estimated at 3%.
    • Accession Number:
      EC 1.5.1.20 (MTHFR protein, human)
      EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
    • Publication Date:
      Date Created: 20181024 Date Completed: 20190115 Latest Revision: 20190115
    • Publication Date:
      20221213
    • Accession Number:
      30351748