Development of catechin-phospholipid complex to enhance the bioavailability and modulatory potential against cadmium-induced oxidative stress in rats liver.

Publisher: Informa Healthcare Country of Publication: England NLM ID: 9510153 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4160 (Electronic) Linking ISSN: 13813455 NLM ISO Abbreviation: Arch Physiol Biochem Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-

Antioxidants/*pharmacology ; Catechin/*pharmacology ; Chemical and Drug Induced Liver Injury/*prevention & control ; Liver/*drug effects ; Oxidative Stress/*drug effects ; Phosphatidylcholines/*pharmacokinetics; Administration, Oral ; Animals ; Antioxidants/chemistry ; Antioxidants/pharmacokinetics ; Biological Availability ; Cadmium Chloride/toxicity ; Catalase/metabolism ; Catechin/chemistry ; Catechin/pharmacokinetics ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Drug Administration Schedule ; Drug Carriers ; Gene Expression/drug effects ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Function Tests ; Male ; Malondialdehyde/metabolism ; Phosphatidylcholines/chemistry ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism

The natural flavonoid (catechin) has been shown to possess a multitude of pharmacological activities. However, oral administrated catechin (CT) failed to fulfil its therapeutic potential due to poor absorption and low bioavailability. Thus, is a pressing need to develop a new approach from to increase its intestinal absorption and improved bioavailability. In this work, we intended the increase the bioavailability of CT by preparing catechin-phospholipid complex (CT-PH) and evaluate the protective effect of CT-PH complex against cadmium caused liver injuries in rats. Oral bioavailability of CT and CT-PH complex was evaluated in rats and the plasma CT was estimated by HPLC analysis. The greater absorption of CT-PH complex rats indicated that improved bioavailability. Liver function markers, lipid peroxidation, protein oxidation, antioxidant status and histopathological changes were determined in normal and treated rats. Moreover, biochemical analysis and histopathological examinations indicated that CT-PH provided better protection to rat liver than free CT.

Keywords: Catechin; Catechin–phospholipid complex; bioavailability; hepatoprotective potential

0 (Antioxidants)
0 (Drug Carriers)
0 (Phosphatidylcholines)
4Y8F71G49Q (Malondialdehyde)
8R1V1STN48 (Catechin)
EC 1.11.1.6 (Catalase)
EC 1.11.1.9 (Glutathione Peroxidase)
EC 1.15.1.1 (Superoxide Dismutase)
GAN16C9B8O (Glutathione)
J6K4F9V3BA (Cadmium Chloride)

Date Created: 20181002 Date Completed: 20200323 Latest Revision: 20200323

20231215

10.1080/13813455.2018.1493608

30269601