Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus.

Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE

Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia

Polymorphism, Single Nucleotide*; Biomarkers/*blood ; Diabetes Mellitus, Type 2/*complications ; Diabetes, Gestational/*physiopathology ; Glucose Intolerance/*diagnosis; Adult ; Blood Glucose/analysis ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Follow-Up Studies ; Glucose Intolerance/blood ; Glucose Intolerance/etiology ; Glucose Tolerance Test ; Glycated Hemoglobin/analysis ; Humans ; Japan ; Middle Aged ; Pregnancy ; Prognosis ; Retrospective Studies ; Young Adult

Aims/introduction: Risk factors of type 2 diabetes mellitus in Japanese women with recent gestational diabetes mellitus are unknown. The objective of the present study was to investigate the clinical and genetic characteristics associated with postpartum abnormal glucose tolerance in Japanese women with gestational diabetes mellitus.
Materials and Methods: A total of 213 Japanese women with recent gestational diabetes mellitus who underwent a postpartum 2-h oral glucose tolerance test were investigated. The association between antepartum clinical characteristics and postpartum abnormal glucose tolerance (diabetes or prediabetes based on the Japan Diabetes Society criteria) was examined. Frequencies of 45 known type 2 diabetes mellitus-associated genetic variants were also compared between women with and without postpartum abnormal glucose tolerance.
Results: A total of 59 women showed postpartum abnormal glucose tolerance (prediabetes, n = 51; diabetes, n = 8). Plasma glucose levels at 1 or 2 h, the insulinogenic index and the insulin secretion-sensitivity index-2 of the antepartum oral glucose tolerance test were independent of postpartum abnormal glucose tolerance risk factors (P = 0.006, P = 0.00002, P = 0.01 and P = 0.006, respectively). Four genetic variants (rs266729 [ADIPOQ], rs6017317 [HNF4A], rs5215 [KCNJ11] and rs7177055 [HMG20A]) showed a nominally significant association with postpartum abnormal glucose tolerance (P < 0.05, respectively). Among these, three were related to insulin secretion. Postpartum abnormal glucose tolerance risk significantly increased with increasing risk-allele number (P = 0.0005; odds ratio 1.91).
Conclusions: Clinical features and genetic variants related to impaired insulin secretion are risk factors of postpartum abnormal glucose tolerance in Japanese women with recent gestational diabetes mellitus.
(© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)

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16gm0510011h0205 Japan Agency for Medical Research and Development (AMED); 16ek0109067h0003 Japan Agency for Medical Research and Development (AMED); 16gk0110013s0801 Japan Agency for Medical Research and Development (AMED); 16gk0110018s0601 Japan Agency for Medical Research and Development (AMED); 26293365 KAKENHI; 26462500 KAKENHI; 26-13 NCCHD of Japan

Keywords: Gestational diabetes; Glucose tolerance test; Single-nucleotide polymorphism

0 (Biomarkers)
0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (hemoglobin A1c protein, human)

Date Created: 20180922 Date Completed: 20190930 Latest Revision: 20231011

20231215

PMC6497595

10.1111/jdi.12935

30239167