Context-dependent functions of KLF4 in cancers: Could alternative splicing isoforms be the key?

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Science Ireland
      Original Publication: Amsterdam, Elsevier/North-Holland.
    • Subject Terms:
      Kruppel-Like Transcription Factors/*genetics ; Neoplasms/*genetics ; Proto-Oncogenes/*genetics ; Tumor Suppressor Proteins/*genetics; Alternative Splicing ; Animals ; Gene Expression Regulation, Neoplastic ; Humans ; Kruppel-Like Factor 4 ; Kruppel-Like Transcription Factors/metabolism ; Neoplasms/classification ; Neoplasms/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Survival Analysis ; Tumor Suppressor Proteins/metabolism
    • Abstract:
      Krüppel-like factor 4 (KLF4) is an important transcription factor that is expressed in a variety of tissues and regulates many critical physiologic and cellular processes, including cell proliferation, differentiation, stem cell reprogramming, maintenance of genomic stability, and normal tissue homeostasis. KLF4 has both tumor suppressive and oncogenic functions in gastrointestinal and other cancers. These functions are thought to be context dependent, but how KLF4 exerts these differential functions and the molecular mechanisms behind them remain poorly understood. Recent studies have shown that the KLF4 gene undergoes alternative splicing, and the protein products of certain transcripts antagonize wild-type KLF4 function, suggesting an additional layer of regulation of KLF4 function. Therefore, detailed study of KLF4 alternative splicing may not only provide new insights into the complexity of KLF4 functions but also lead to rational targeting of KLF4 for cancer prevention and therapy.
      (Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Alternative splicing; Cancer; Context-dependent function; KLF4
    • Accession Number:
      0 (KLF4 protein, human)
      0 (Kruppel-Like Factor 4)
      0 (Kruppel-Like Transcription Factors)
      0 (Protein Isoforms)
      0 (Tumor Suppressor Proteins)
    • Publication Date:
      Date Created: 20180916 Date Completed: 20190930 Latest Revision: 20211204
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.canlet.2018.09.005
    • Accession Number:
      30217565