Effects of the injectable contraceptive depot medroxyprogesterone acetate in Thai women with liver fluke infestation: results after six months.

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  • Additional Information
    • Source:
      Publisher: World Health Organization Country of Publication: Switzerland NLM ID: 7507052 Publication Model: Print Cited Medium: Print ISSN: 0042-9686 (Print) Linking ISSN: 00429686 NLM ISO Abbreviation: Bull World Health Organ Subsets: MEDLINE
    • Publication Information:
      Original Publication: Geneva : World Health Organization,
    • Subject Terms:
      Liver Function Tests*; Contraceptive Agents, Female/*pharmacology ; Medroxyprogesterone/*pharmacology ; Opisthorchiasis/*metabolism; Adolescent ; Adult ; Delayed-Action Preparations ; Female ; Humans ; Injections ; Middle Aged ; Time Factors
    • Abstract:
      The effect of the three-monthly injectable contraceptive depot medroxyprogesterone acetate (DMPA) on liver and lipid function was assessed in Thai women with liver fluke (Opisthorchis viverrini) infestation, DMPA administration being started in the immediate postpartum period. Immediate postpartum IUD and sterilization acceptors with fluke infestation were recruited as a comparison (control) group for the fluke-positiv DMPA acceptors. Comparable groups of fluke-negative acceptors were recruited in an area of Thailand free of liver fluke transmission. Results are presented for the first 6 follow-up months for 170 DMPA and 177 control fluke-positive subjects and for 153 DMPA and 150 control fluke-negative subjects. Small and similar increases occurred in each of the four groups for alanine amino transferase, isocitrate dehydrogenase, and total bilirubin levels while aspartate amino transferase levels changed less in the DMPA groups than in their respective control groups. None of the subjects in either DMPA group had clearly abnormal results in these tests at 6 months. Alkaline phosphatase, cholesterol, and triglycerides levels were markedly lower in each group at 6 months than in the puerperal specimens. There was a greater decrease in triglycerides levels in both DMPA groups than in their respective control groups. However, the decrease in the alkaline phosphatase and cholesterol levels was greater only in the fluke-positive DMPA group than in the fluke-positive control group. None of these biochemical results were related to differences in age, parity, or lactation status between the groups. The results indicate that DMPA did not cause any early deleterious effects in the metabolic factors studied in women with liver fluke infestation.
    • References:
      Am J Obstet Gynecol. 1950 Jan;59(1):148-54. (PMID: 15408712)
      J Obstet Gynaecol Br Commonw. 1963 Aug;70:693-700. (PMID: 14078049)
      Am J Obstet Gynecol. 1960 Jul;80:104-7. (PMID: 13834923)
      Am J Clin Pathol. 1959 Feb;31(2):155-9. (PMID: 13626905)
      Am J Obstet Gynecol. 1950 Oct;60(4):731-40. (PMID: 14771167)
      Am J Trop Med Hyg. 1966 Nov;15(6):914-8. (PMID: 5959105)
      Asian Med J. 1973 Apr;9(4):133-5. (PMID: 12262537)
      Acta Obstet Gynecol Scand. 1975;54(5):437-42. (PMID: 1202904)
      J Obstet Gynaecol Br Commonw. 1972 Jul;79(7):657-60. (PMID: 5043432)
      Lancet. 1972 Oct 21;2(7782):876. (PMID: 4116580)
      Am J Trop Med Hyg. 1971 Sep;20(5):667-71. (PMID: 5093663)
      Am J Clin Pathol. 1965 Dec;44(6):654-61. (PMID: 5891840)
      Obstet Gynecol. 1974 Jan;43(1):31-40. (PMID: 4808962)
    • Accession Number:
      0 (Contraceptive Agents, Female)
      0 (Delayed-Action Preparations)
      HSU1C9YRES (Medroxyprogesterone)
    • Publication Date:
      Date Created: 19770101 Date Completed: 19771031 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC2366617
    • Accession Number:
      302157