Positive correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy: a multicenter retrospective study.

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  • Additional Information
    • Source:
      Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
    • Publication Information:
      Publication: Nov. 2012- : London : Sage Publications
      Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.
    • Subject Terms:
      Cognitive Dysfunction/*etiology ; Diabetes Mellitus, Type 2/*physiopathology ; Diabetic Nephropathies/*complications ; Kidney Diseases/*etiology ; Thrombotic Microangiopathies/*etiology; Adult ; Aged ; Cognitive Dysfunction/pathology ; Diabetic Nephropathies/pathology ; Female ; Follow-Up Studies ; Humans ; Kidney Diseases/pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Retrospective Studies ; Thrombotic Microangiopathies/pathology
    • Abstract:
      Objective: This study was performed to explore the correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy (T2DN) by detecting changes in cognitive function and cerebral metabolism in these patients with different stages of T2DN.
      Methods: Prospectively maintained databases were reviewed from 2006 to 2017. Blood biochemical indexes and the urinary albumin excretion rate (UAER) were measured in all participants. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA). Cognitive impairment was the primary endpoint. Renal microangiopathy was the secondary endpoint. Pearson correlation analysis was used to assess correlations.
      Results: Two hundred sixteen patients with type 2 diabetes mellitus (T2DM) were divided into three groups according to their UAER: T2DM without nephropathy (n=72), early T2DM with nephropathy (n=74), and the clinical stage of early T2DM with nephropathy (n=70). Healthy participants were selected as the normal control group (n=70). Pearson correlation analysis demonstrated that the total MMSE and MoCA score was negatively correlated with the UAER (r=-0.327) and positively correlated with the estimated glomerular filtration rate (r=0.428) in patients with T2DN.
      Conclusions: The present study showed a positive correlation between cognitive impairment and renal microangiopathy in patients with T2DN.
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    • Contributed Indexing:
      Keywords: Diabetic nephropathy; cognitive impairment; correlation; glomerular filtration rate; renal microangiopathy; urinary albumin excretion rate
    • Publication Date:
      Date Created: 20180914 Date Completed: 20190708 Latest Revision: 20200309
    • Publication Date:
      20240628
    • Accession Number:
      PMC6300957
    • Accession Number:
      10.1177/0300060518789299
    • Accession Number:
      30208748