Anti-Atopic Properties of Gracillin Isolated from Dioscorea quinqueloba on 2,4-Dinitrochlorobenzene-Induced Skin Lesions in Mice.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
      Dinitrochlorobenzene* ; Dioscorea*/chemistry; Anti-Inflammatory Agents/*pharmacology ; Dermatitis, Atopic/*prevention & control ; Dermatologic Agents/*pharmacology ; Plant Extracts/*pharmacology ; Skin/*drug effects ; Spirostans/*pharmacology; Animals ; Anti-Inflammatory Agents/isolation & purification ; Cell Line, Tumor ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Dermatologic Agents/isolation & purification ; Disease Models, Animal ; Female ; Immunoglobulin E/blood ; Interleukin-4/blood ; Mice, Hairless ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Rats ; Skin/metabolism ; Skin/pathology ; Spirostans/isolation & purification ; Water Loss, Insensible/drug effects
    • Abstract:
      Naturally occurring saponins have been reported to have anti-inflammatory and immunomodulatory effects. However, the effects of gracillin, a main saponin component of Dioscorea quinqueloba ( D. quinqueloba ), on atopic dermatitis (AD), have not been previously studied. The aim of this study was to determine whether gracillin isolated from D. quinqueloba has an anti-AD effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Topical co-treatment of gracillin and DNCB for two weeks markedly reduced symptoms typical of AD (redness, itching, swelling and skin lichenification), decreased transepidermal water loss (TEWL) and increased skin hydration. In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice. Our results suggest gracillin is a potential candidate for the prevention and treatment of AD and other inflammatory skin disorders.
    • References:
      Biosci Biotechnol Biochem. 2003 Jul;67(7):1451-6. (PMID: 12913286)
      J Am Acad Dermatol. 2002 Feb;46(2):228-41. (PMID: 11807435)
      Lancet. 2016 Jan 2;387(10013):40-52. (PMID: 26454361)
      J Dermatol Sci. 2010 Apr;58(1):1-7. (PMID: 20207111)
      Crit Rev Food Sci Nutr. 2007;47(3):231-58. (PMID: 17453922)
      Br J Dermatol. 1999 Feb;140(2):264-7. (PMID: 10233220)
      Immunol Rev. 2011 Jul;242(1):233-46. (PMID: 21682749)
      Vet Dermatol. 2011 Jun;22(3):239-48. (PMID: 21414049)
      Br J Dermatol. 2000 May;142(5):931-6. (PMID: 10809850)
      Am J Clin Dermatol. 2003;4(11):771-88. (PMID: 14572299)
      Acta Derm Venereol. 1985;65(2):102-5. (PMID: 2408409)
      J Allergy Clin Immunol. 2014 Oct;134(4):818-23. (PMID: 25282563)
      Phytomedicine. 1996 Mar;2(4):363-86. (PMID: 23194774)
      Nutrients. 2017 Dec 05;9(12):null. (PMID: 29206209)
      Phytochemistry. 2016 Oct;130:22-46. (PMID: 27374482)
      BMJ. 2003 Oct 25;327(7421):942-3. (PMID: 14576221)
      Clin Exp Immunol. 1993 Apr;92(1):120-4. (PMID: 8467557)
      J Allergy Clin Immunol. 2006 Jul;118(1):3-21; quiz 22-3. (PMID: 16815133)
      BMJ. 2002 Jun 29;324(7353):1533-4. (PMID: 12089073)
      Curr Med Res Opin. 2010 Mar;26(3):633-40. (PMID: 20070141)
      J Allergy Clin Immunol. 2011 May;127(5):1110-8. (PMID: 21388665)
      Phytomedicine. 2014 Jul-Aug;21(8-9):1053-61. (PMID: 24854572)
      Front Pharmacol. 2015 Oct 26;6:237. (PMID: 26578954)
      J Am Acad Dermatol. 2003 Mar;48(3):352-8. (PMID: 12637914)
      J Biomed Sci. 2006 Sep;13(5):613-9. (PMID: 16847722)
      J Invest Dermatol. 1992 Oct;99(4):403-8. (PMID: 1401997)
      J Clin Invest. 2004 Mar;113(5):651-7. (PMID: 14991059)
      Eur J Immunol. 1989 Jul;19(7):1311-5. (PMID: 2788092)
    • Contributed Indexing:
      Keywords: 2,4-dinitrochlorobenzene; Dioscorea quinqueloba; atopic dermatitis; gracillin; interleukin 4; skin barrier recovery
    • Accession Number:
      0 (Anti-Inflammatory Agents)
      0 (Dermatologic Agents)
      0 (Dinitrochlorobenzene)
      0 (Plant Extracts)
      0 (Spirostans)
      19083-00-2 (gracillin)
      207137-56-2 (Interleukin-4)
      37341-29-0 (Immunoglobulin E)
    • Publication Date:
      Date Created: 20180912 Date Completed: 20190110 Latest Revision: 20201209
    • Publication Date:
      20231215
    • Accession Number:
      PMC6164938
    • Accession Number:
      10.3390/nu10091205
    • Accession Number:
      30200442