Establishing intra- and inter-vendor reproducibility of T 1 relaxation time measurements with 3T MRI.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : New York, NY : Wiley
      Original Publication: San Diego : Academic Press,
    • Subject Terms:
      Brain/*diagnostic imaging ; Magnetic Resonance Imaging/*standards; Adult ; Algorithms ; Calibration ; Cerebellum/diagnostic imaging ; Female ; Gray Matter/diagnostic imaging ; Healthy Volunteers ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/instrumentation ; Male ; Pattern Recognition, Automated ; Reproducibility of Results ; Software ; White Matter/diagnostic imaging
    • Abstract:
      Purpose: Parametric imaging methods (e.g., T 1 relaxation time mapping) have been shown to be more reproducible across time and vendors than weighted (e.g., T 1 -weighted) images. The purpose of this work was to more extensively evaluate the validity of this assertion.
      Methods: Seven volunteers underwent twice-repeated acquisitions of variable flip-angle T 1 mapping, including B 1 + calibration, on a 3T Philips Achieva and 3T Siemens Trio scanner. Intra-scanner and inter-vendor T 1 variability were calculated. To determine T 1 reproducibility levels in longitudinal settings, or after changing hardware or software, four additional data sets were acquired from two of the participants; one participant was scanned on a different 3T Siemens Trio scanner and another on the same 3T Philips Achieva scanner but after a software upgrade.
      Results: Intra-scanner variability of voxel-wise T 1 values was consistent between the two vendors, averaging 0.7/0.7/1.3/1.4% in white matter/cortical gray matter/subcortical gray matter/cerebellum, respectively. We observed, however, a systematic bias between the two vendors of https://doi.org/10.0/7.8/8.6/10.0%, respectively. The T 1 bias across two scanners of the same model was greater than intra-scanner variability, although still only at 1.4/1.0/1.9/2.3%, respectively. A greater bias was identified for data sets acquired before/after software upgrade in white matter/cortical gray matter (3.6/2.7%) whereas variability in subcortical gray matter/cerebellum was comparable (1.7/1.9%).
      Conclusion: We established intra- and inter-vendor reproducibility levels for a widely used T 1 mapping protocol. We anticipate that these results will guide the design of multi-center studies, particularly those encompassing multiple vendors. Furthermore, this baseline level of reproducibility should be established or surpassed during the piloting phase of such studies.
      (© 2018 International Society for Magnetic Resonance in Medicine.)
    • Grant Information:
      203147/Z/16/Z United Kingdom WT_ Wellcome Trust; International MRC; MR/R000050/1 United Kingdom MRC_ Medical Research Council; MR/R000050/1 International Spinal Research Charity ERA-NET Neuron; International Roger De Spoelberch Foundation; Switzerland SNSF_ Swiss National Science Foundation; 31360442 International National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: 3T; T1 relaxation; bias; multi-vendor; parametric imaging; reproducibility
    • Publication Date:
      Date Created: 20180831 Date Completed: 20191230 Latest Revision: 20210109
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/mrm.27421
    • Accession Number:
      30159953