Efficacy and Radiation Exposure of Ultra-Low-Dose Chest CT at 100 kVp with Tin Filtration in CT-Guided Percutaneous Core Needle Biopsy for Small Pulmonary Lesions Using a Third-Generation Dual-Source CT Scanner.

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  • Author(s): Li C;Li C; Liu B; Liu B; Meng H; Meng H; Lv W; Lv W; Jia H; Jia H
  • Source:
    Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2019 Jan; Vol. 30 (1), pp. 95-102. Date of Electronic Publication: 2018 Aug 24.
  • Publication Type:
    Comparative Study; Journal Article; Randomized Controlled Trial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Society of Cardiovascular and Interventional Radiology Country of Publication: United States NLM ID: 9203369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7732 (Electronic) Linking ISSN: 10510443 NLM ISO Abbreviation: J Vasc Interv Radiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Reston, Va. : Society of Cardiovascular and Interventional Radiology, c1990-
    • Subject Terms:
      Radiation Dosage* ; Tomography, X-Ray Computed*; Image-Guided Biopsy/*methods ; Lung Neoplasms/*pathology ; Radiation Exposure/*prevention & control; Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle ; China ; Feasibility Studies ; Female ; Humans ; Image-Guided Biopsy/adverse effects ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Radiation Exposure/adverse effects ; Reproducibility of Results ; Risk Factors ; Tumor Burden
    • Abstract:
      Purpose: To prospectively investigate efficacy and radiation dose of ultra-low-dose CT-guided percutaneous core needle biopsy (PCNB) at 100 kVp with tin filtration ( 100 Sn kVp) for small pulmonary lesions.
      Materials and Methods: Study enrolled and randomly assigned 210 patients to standard-dose CT (n = 70) or ultra-low-dose CT (n = 140; 1:2 randomization scheme) protocol. Standard-dose CT settings were reference 110 kVp and 50 mAs, and ultra-low-dose CT settings were fixed at 100 Sn kVp and 70 mAs. All PCNBs in patients with small pulmonary lesions (< 3 cm) were performed on a third-generation dual-source CT scanner. Diagnostic performance, complication rate, image quality, and radiation dose were compared.
      Results: Sensitivity, specificity, and accuracy for diagnosis of malignancy were 95.7%, 100%, and 96.9% with standard-dose CT and 93.8%, 100%, and 95.4% with ultra-low-dose CT (P > .05). Complication rate showed no significant differences between protocols (P > .05). Mean volume CT dose index) and total dose-length product were significantly lower in ultra-low-dose CT compared with standard-dose CT (0.24 mGy vs 3.3 mGy ± 1.1 and 9.84 mGy-cm ± 0.70 vs 110.5 mGy-cm ± 45.1; P < .001). Effective dose for ultra-low-dose CT was significantly lower than that for standard-dose CT (0.14 mSv ± 0.02 vs 1.78 mSv ± 0.76; -92.1%; P < .001). Image quality of ultra-low-dose CT met the requirements of PCNB.
      Conclusions: Ultra-low-dose CT-guided PCNB at 100 Sn kVp spectral shaping significantly reduced radiation dose on a third-generation dual-source CT, while maintaining high diagnostic accuracy and safety for small pulmonary lesions.
      (Copyright © 2018 SIR. Published by Elsevier Inc. All rights reserved.)
    • Publication Date:
      Date Created: 20180829 Date Completed: 20190506 Latest Revision: 20190506
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jvir.2018.06.013
    • Accession Number:
      30149997