[Intestinal cross-talk : The gut as motor of multiple organ failure].

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  • Author(s): Druml W;Druml W
  • Source:
    Medizinische Klinik, Intensivmedizin und Notfallmedizin [Med Klin Intensivmed Notfmed] 2018 Sep; Vol. 113 (6), pp. 470-477. Date of Electronic Publication: 2018 Aug 17.
  • Publication Type:
    Journal Article; Review
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Intestinaler Crosstalk : Der Darm als Motor des Multiorganversagens.
    • Source:
      Publisher: Springer Medizin Country of Publication: Germany NLM ID: 101575086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2193-6226 (Electronic) Linking ISSN: 21936218 NLM ISO Abbreviation: Med Klin Intensivmed Notfmed Subsets: MEDLINE
    • Publication Information:
      Original Publication: Heidelberg : Springer Medizin
    • Subject Terms:
      Intestines*/physiopathology ; Intra-Abdominal Hypertension* ; Multiple Organ Failure*; Critical Illness ; Humans ; Intestinal Mucosa
    • Abstract:
      The central role of the organ system "gut" for critically ill patients has not been acknowledged until the last decade. The gut is a crucial immunologic, metabolic and neurologic organ system and impairment of its functions is associated with morbidity and mortality. The gut has a central position in the cross-talk between organs and dysfunction of the gut may result in impairment of other intra-abdominal and extra-abdominal organ systems. The intestinal tract is the most important source of endogenous infections and determines the inflammatory status of the organism. Gut failure is an element of the multiple organ dysfunction syndrome (MODS). The leading mechanism in the evolution of endogenous infections is the intestinal translocation of microbes. A dysbiosis and damage of the intestinal mucosa leads to a disorder of the mucosal barrier function, increases the permeability and promotes translocation (leaky gut hypothesis). A further crucial mechanism of organ interactions is the increase in intra-abdominal pressure. Intra-abdominal hypertension promotes further injury of the gut, increases translocation and inflammation and causes dysfunction of other organ systems, such as the kidneys, the cardiovascular system and the lungs. Maintaining and/or restoring intestinal functions must be a priority of any intensive care therapy. The most important measure is early enteral nutrition. Other measures are the preservation of motility and modulation of the intestinal microbiome. Intra-abdominal hypertension must be reduced by an individually adapted infusion therapy, positioning of the patient, administration of drugs (abdominal compliance) and decompression (by tubes, endoscopically or in severe cases surgically).
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    • Contributed Indexing:
      Keywords: Bacterial translocation; Enteral nutrition; Intra-abdominal hypertension; Microbiome; Probiotics
    • Publication Date:
      Date Created: 20180819 Date Completed: 20190529 Latest Revision: 20190529
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00063-018-0475-1
    • Accession Number:
      30120495