Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW).

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Wiley-Blackwell, c1999-
    • Subject Terms:
      Sex Factors*; Caloric Restriction/*methods ; Diabetes Mellitus, Type 2/*prevention & control ; Overweight/*diet therapy ; Prediabetic State/*diet therapy; Adult ; Aged ; Australia ; Blood Glucose ; Body Mass Index ; Cholesterol, HDL/blood ; Diabetes Mellitus, Type 2/etiology ; Europe ; Female ; Humans ; Insulin Resistance ; Life Style ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/diet therapy ; Metabolic Syndrome/physiopathology ; Middle Aged ; New Zealand ; Overweight/complications ; Overweight/physiopathology ; Prediabetic State/etiology ; Prediabetic State/physiopathology ; Time Factors ; Treatment Outcome ; Weight Loss/physiology
    • Abstract:
      Aims: The PREVIEW lifestyle intervention study (ClinicalTrials.gov Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type-2 diabetes. We hypothesized that the initial, fixed low-energy diet (LED) would induce different metabolic outcomes in men vs women.
      Materials and Methods: All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI ≥ 25 kg/m 2 ) individuals with pre-diabetes according to ADA-criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat-free mass (FFM) and metabolic syndrome Z-score.
      Results: In total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow-up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA-IR decreased by 1.50 ± 0.15 in men and by 1.35 ± 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z-score, C-peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo-glycaemia.
      Conclusions: An 8-week LED induced different effects in women than in men. These findings are clinically important and suggest gender-specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.
      (© 2018 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)
    • References:
      Nutrients. 2017 Jun 20;9(6):. (PMID: 28632180)
      PLoS One. 2013 Jul 30;8(7):e65174. (PMID: 23935815)
      Diabet Med. 2002 Sep;19(9):708-23. (PMID: 12207806)
      Swiss Med Wkly. 2013 Jan 21;143:w13721. (PMID: 23348658)
      Diabetes Care. 2004 Jun;27(6):1487-95. (PMID: 15161807)
      Am J Clin Nutr. 1999 May;69(5):904-12. (PMID: 10232629)
      Exerc Sport Sci Rev. 2014 Jul;42(3):92-101. (PMID: 24949844)
      Front Psychol. 2016 Aug 10;7:1136. (PMID: 27559319)
      Diabetes Care. 2017 Jan;40(Suppl 1):S11-S24. (PMID: 27979889)
      Am J Cardiol. 2007 Dec 15;100(12):1759-66. (PMID: 18082522)
      Pediatr Exerc Sci. 2018 Aug 1;30(3):402-410. (PMID: 29543127)
      Food Nutr Bull. 2005 Mar;26(1):166. (PMID: 15810802)
      Diabetes Obes Metab. 2009 Jun;11(6):596-602. (PMID: 19383030)
      BMJ. 2016 Nov 23;355:i5953. (PMID: 27881363)
      JAMA. 2014 Sep 3;312(9):943-52. (PMID: 25182103)
      Diabetes Care. 2009 Feb;32(2):287-94. (PMID: 19017771)
      Eur J Cardiovasc Prev Rehabil. 2005 Oct;12(5):451-8. (PMID: 16210931)
      Diabetes Care. 2009 Nov;32(11):2133-5. (PMID: 19875608)
      J Intern Med. 2003 Apr;253(4):463-71. (PMID: 12653876)
      Hypertens Res. 2016 Sep;39(9):640-7. (PMID: 27194570)
      Am J Clin Nutr. 2008 May;87(5):1141-7. (PMID: 18469232)
      Metabolism. 2017 Mar;68:119-132. (PMID: 28183444)
      Circulation. 2009 Oct 20;120(16):1640-5. (PMID: 19805654)
      Obes Rev. 2015 Feb;16(2):171-86. (PMID: 25494712)
      J Diabetes Investig. 2015 Sep;6(5):553-9. (PMID: 26417413)
      Eur J Clin Nutr. 2010 Sep;64(9):994-9. (PMID: 20588292)
      Arch Dis Child. 2006 Jul;91(7):612-7. (PMID: 16790722)
      Int J Behav Nutr Phys Act. 2014 May 16;11:64. (PMID: 24886191)
      Clin Obes. 2011 Feb;1(1):31-40. (PMID: 25586973)
      Diabetes Obes Metab. 2018 Dec;20(12):2840-2851. (PMID: 30088336)
      J Surg Res. 2013 Nov;185(1):1-5. (PMID: 23845864)
      N Engl J Med. 2010 Nov 25;363(22):2102-13. (PMID: 21105792)
      Br J Nutr. 1995 Mar;73(3):337-47. (PMID: 7766558)
      Eur J Intern Med. 2014 Dec;25(10):922-5. (PMID: 25468739)
      Diabetes Care. 2003 Dec;26(12):3230-6. (PMID: 14633807)
      Public Health. 2014 Sep;128(9):811-3. (PMID: 25194299)
      Am J Clin Nutr. 2013 May;97(5):990-4. (PMID: 23535105)
      Obes Res. 1998 Nov;6(6):393-9. (PMID: 9845228)
      Am J Clin Nutr. 2017 Sep;106(3):755-763. (PMID: 28747328)
      JAMA. 2009 Apr 15;301(15):1588-90. (PMID: 19366779)
      Med Sci Sports Exerc. 2007 Aug;39(8):1423-34. (PMID: 17762377)
      Eur J Clin Nutr. 2012 Apr;66(4):504-9. (PMID: 22190136)
    • Contributed Indexing:
      Keywords: dietary intervention; obesity; pre-diabetes; prevention; weight loss
    • Molecular Sequence:
      ClinicalTrials.gov NCT01777893
    • Accession Number:
      0 (Blood Glucose)
      0 (Cholesterol, HDL)
    • Publication Date:
      Date Created: 20180809 Date Completed: 20190531 Latest Revision: 20210109
    • Publication Date:
      20240628
    • Accession Number:
      PMC6282840
    • Accession Number:
      10.1111/dom.13466
    • Accession Number:
      30088336