[Hypoglycemic effects of mulberry leaf extracts on diabetic mice].

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  • Additional Information
    • Source:
      Publisher: Wei sheng yan jiu" bian ji bu Country of Publication: China NLM ID: 9426367 Publication Model: Print Cited Medium: Print ISSN: 1000-8020 (Print) Linking ISSN: 10008020 NLM ISO Abbreviation: Wei Sheng Yan Jiu Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing Shi : "Wei sheng yan jiu" bian ji bu
      Original Publication: Beijing Shi : "Wei sheng yan jiu" bian ji bu,
    • Subject Terms:
      Plant Extracts*; Blood Glucose/*drug effects ; Diabetes Mellitus, Experimental/*drug therapy ; Hypoglycemic Agents/*therapeutic use ; Plant Leaves/*chemistry; Animals ; Insulin ; Insulin Resistance ; Mice ; Morus
    • Abstract:
      Objective: To study hypoglycemic effects of different mulberry leaf extracts on diabetic mice.
      Methods: STZ-induced diabetic mice were intragastricly administrated with different mulberry leaf extracts( water extracts: 800 mg/kg, ethanol extracts: 500 mg/kg, water extracts + ethanol extracts: low dose 150 mg/kg, high dose300 mg/kg) and positive control group( melbine: 227. 5 mg/kg). Four weeks later, serum glucose levels, insulin levels, antioxidase activities were tested. Liver and pancreas pathological changes were observed by HE staining.
      Results: Compared with model group, each mulberry leaf extracts group could decrease serum glucose and insulin levels and increase antioxidase activities. The mixture of water extracts and ethanol extracts at high dose showed the most obvious effects. In this group, serum glucose levels, insulin levels, insulin resistance index and insulin sensitivity index were 61. 0%, 64. 1%, 42. 9% and 1. 18 times of those in the model group( P < 0. 05), and no significant differences were found between this group and the positive group( P > 0. 05).
      Conclusion: The mixture of mulberry leaf water and ethanol extracts showed synergistic hypoglycemic effects by increasing antioxidase activities, repairing pancrea and liver oxidative damages, and improving insulin resistance status.
    • Contributed Indexing:
      Keywords: anti-oxidation; ethanol extracts; hypoglycemic effects; mulberry leaf; water extracts
    • Accession Number:
      0 (Blood Glucose)
      0 (Hypoglycemic Agents)
      0 (Insulin)
      0 (Plant Extracts)
    • Publication Date:
      Date Created: 20180808 Date Completed: 20181218 Latest Revision: 20181218
    • Publication Date:
      20231215
    • Accession Number:
      30082012