YKL-40: A biomarker for early nephropathy in type 2 diabetic patients and its association with inflammatory cytokines.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: Amsterdam : Elsevier
      Original Publication: Stuttgart ; New York, Fischer.
    • Subject Terms:
      Albuminuria/*diagnosis ; Biomarkers/*blood ; Chitinase-3-Like Protein 1/*blood ; Diabetes Mellitus, Type 2/*diagnosis ; Diabetic Nephropathies/*diagnosis; Adult ; Aged ; Albuminuria/immunology ; Cytokines/metabolism ; Diabetes Mellitus, Type 2/immunology ; Diabetic Nephropathies/immunology ; Disease Progression ; Early Diagnosis ; Female ; Humans ; India ; Inflammation Mediators/metabolism ; Male ; Middle Aged ; Prognosis
    • Abstract:
      Diabetic Nephropathy (DN) is an important cause of morbidity and death amongst diabetes. Persistent micro and macroalbuminuria are well known predictors of DN leading to progressive end-stage renal disease. However, albuminuria has several limitations. Increasing evidences show that YKL-40 is highly expressed in variety of inflammatory diseases and also recognized as a non-invasive prognostic biomarker for inflammation. In the present study, we measured plasma YKL-40 levels in different stages of albuminuria and assessed its diagnostic accuracy as a biomarker for DN and correlated with different families of circulatory cytokines. A total of 306 subjects were recruited and divided into three groups [Group-I, control (n = 83), Group-II, Normoalbuminuria (n = 81), Group-III, DN (n = 142)]. Group-III is further subdivided into: Group-IIIa, microalbuminuria (n = 73), Group-IIIb, macroalbuminuria (n = 69). The median levels of YKL-40 (p = 0.001) showed a marked stepwise increase from normo to macroalbuminuria and positively correlated with eGFR. The AUC ROC for YKL-40 was found to be high [0.95; (95% CI: 0.88-1.0)], when compared to other acute phase markers. Plasma YKL-40 showed a positive correlation with LIGHT/TNFSF14, sIL-6Ra, gp130/sIL-6Rβ, IFN-β, IL-8, TNFSF14, sCD-30 and eGFR meanwhile a negative correlation with TWEAK/TNFSF12, IL-7 like cytokine and IFN-λ2. Plasma YKL-40 could be a potential biomarker for early diagnosis of incipient DN among South Indian population.
      (Copyright © 2018 Elsevier GmbH. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cytokines; Diabetic Nephropathy; Inflammation; Type-2-diabetes; YKL-40
    • Accession Number:
      0 (Biomarkers)
      0 (CHI3L1 protein, human)
      0 (Chitinase-3-Like Protein 1)
      0 (Cytokines)
      0 (Inflammation Mediators)
    • Publication Date:
      Date Created: 20180806 Date Completed: 20190625 Latest Revision: 20190625
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.imbio.2018.07.020
    • Accession Number:
      30077474