Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses.

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  • Additional Information
    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7910920 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2885 (Electronic) Linking ISSN: 01407783 NLM ISO Abbreviation: J Vet Pharmacol Ther Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, Blackwell Scientific Publications.
    • Subject Terms:
      Food Deprivation*; Cyclooxygenase 2 Inhibitors/*pharmacokinetics ; Horses/*blood ; Imidazoles/*pharmacokinetics ; Sulfones/*pharmacokinetics; Administration, Oral ; Animals ; Area Under Curve ; Cyclooxygenase 2 Inhibitors/administration & dosage ; Cyclooxygenase 2 Inhibitors/chemistry ; Female ; Half-Life ; Imidazoles/administration & dosage ; Imidazoles/chemistry ; Male ; Molecular Structure ; Random Allocation ; Sulfones/administration & dosage ; Sulfones/chemistry
    • Abstract:
      The pharmacokinetic properties of vitacoxib have not been established completely; current dosage recommendations are based on clinical experiences. The primary objective of this study was to describe plasma concentrations and characterize the pharmacokinetics of vitacoxib formulation following oral administrations in horses. Also, the effect of the state of stomach contents on the absorption of vitacoxib was investigated in fed/fasted horses. Blood samples were collected prior to and at various times up to 72 hr post-administration. Drug concentrations were measured using ultra high-performance liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were calculated using Non-Compartmental Analysis Model 200 in WinNonlin™ software. No complications resulting from the vitacoxib administration were noted. All procedures were tolerated well by the horses throughout the study. C max was 17.5 ± 9.36 ng/ml (fasted) and 9.47 ± 3.53 ng/ml (fed) following oral administrations. AUC last was 173.7 ± 137.9 ng hr/ml (fasted) and 113.2 ± 70.8 ng h/ml (fed). No significant differences in pharmacokinetic parameters were noted and the results from the pharmacokinetic analysis were similar between the studies, regardless of precision of dosage and fasted and fed conditions. The study extends previous studies describing the pharmacokinetics of vitacoxib following p.o. administration to the horses. Further studies investigating the pharmacokinetics/pharmacodynamics of vitacoxib are necessary to establish adequate therapeutic protocols (optimal dosage and frequency of administration) in horses.
      (© 2018 John Wiley & Sons Ltd.)
    • Grant Information:
      31672599 National Natural Science Foundation; 2016YFD0501309-1 Projects in the National Science & Technology Pillar Program during the Thirteenth Five-Year Plan Period; GJFP2018700701 Quality & Safety Risk Assessment for Animal Products on Chemical Hazards Foundation of China
    • Contributed Indexing:
      Keywords: NSAIDs; Vitacoxib; fasted and fed; horses; pharmacokinetics
    • Accession Number:
      0 (Cyclooxygenase 2 Inhibitors)
      0 (Imidazoles)
      0 (Sulfones)
      0 (vitacoxib)
    • Publication Date:
      Date Created: 20180805 Date Completed: 20190114 Latest Revision: 20190114
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/jvp.12703
    • Accession Number:
      30076623