Perspectives on copper biochemistry.

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  • Author(s): Frieden E
  • Source:
    Clinical physiology and biochemistry [Clin Physiol Biochem] 1986; Vol. 4 (1), pp. 11-9.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Zuchschwerdt Verlag Country of Publication: Germany NLM ID: 8305885 Publication Model: Print Cited Medium: Print ISSN: 0252-1164 (Print) Linking ISSN: 02521164 NLM ISO Abbreviation: Clin Physiol Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: Munchen : Zuchschwerdt Verlag
      Original Publication: Basel ; New York : S. Karger, 1983-[1993]
    • Subject Terms:
      Receptors, Immunologic* ; Receptors, Peptide*; Copper/*metabolism; Adult ; Animals ; Biological Transport ; Carrier Proteins/analysis ; Carrier Proteins/metabolism ; Carrier Proteins/physiology ; Ceruloplasmin/analysis ; Ceruloplasmin/metabolism ; Ceruloplasmin/physiology ; Copper/deficiency ; Copper/physiology ; Humans ; Metal Metabolism, Inborn Errors ; Metallothionein/physiology ; Oxidoreductases/metabolism ; Receptors, Cell Surface/physiology ; Trace Elements
    • Abstract:
      The biochemistry of the essential trace element copper has been outlined. Following absorption, Cu(II) is transported by serum albumin and transcuprein to the liver where it is incorporated into the plasma Cu-protein, ceruloplasmin, or, possibly, stored as Cu-metallothionein or as superoxide dismutase. Ceruloplasmin is the long-term copper transporter and carries Cu(II) to the tissues for the biosynthesis of key Cu(II) enzymes, especially cytochrome c oxidase, lysyl oxidase and others. The production of copper enzymes raises many new questions about the metabolism of copper. Since ceruloplasmin is the centerpiece of copper metabolism and function, we conclude with more details on its chemistry and multifunctions. This Cu-protein of 132,000 daltons has now been totally sequenced and the copper-containing active sites located. Finally, we have proposed seven possible functions for ceruloplasmin, and there is now good evidence for the existence of ceruloplasmin receptors to expedite some of these functions.
    • Number of References:
      15
    • Grant Information:
      AM 33540 United States AM NIADDK NIH HHS
    • Accession Number:
      0 (Carrier Proteins)
      0 (Receptors, Cell Surface)
      0 (Receptors, Immunologic)
      0 (Receptors, Peptide)
      0 (Trace Elements)
      0 (ceruloplasmin receptor)
      0 (copper-binding protein)
      789U1901C5 (Copper)
      9038-94-2 (Metallothionein)
      EC 1.- (Oxidoreductases)
      EC 1.16.3.1 (Ceruloplasmin)
    • Publication Date:
      Date Created: 19860101 Date Completed: 19860507 Latest Revision: 20131121
    • Publication Date:
      20250114
    • Accession Number:
      3006968