Chronic venous insufficiency: a new concept to understand pathophysiology at the microvascular level - a pilot study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 8700166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-111X (Electronic) Linking ISSN: 02676591 NLM ISO Abbreviation: Perfusion Subsets: MEDLINE
    • Publication Information:
      Publication: London : SAGE Publications
      Original Publication: [London] : Edward Arnold, [c1986-
    • Subject Terms:
      Skin/*blood supply ; Varicose Ulcer/*physiopathology ; Venous Insufficiency/*physiopathology; Aged ; Chronic Disease ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Regional Blood Flow ; Varicose Ulcer/therapy ; Venous Insufficiency/therapy ; Wound Healing
    • Abstract:
      Objectives: The real mechanism for the development of the later stages of chronic venous insufficiency still remains unclear. Venous hypervolemia and microvascular ischemia have been reported to be the consequences of venous insufficiency. The aim of this study was to investigate the effects of induced venous hypovolemia by dorsiflexion exercise in patients with venous leg ulcers.
      Methods: Thirty-six participants, all of whom had an ankle brachial pressure index between 0.8 and 1.2 mmHg, were chosen for this study. The participants were divided into two groups: Group A, a non-exercise group and Group B which performed regular exercise in the form of dorsiflexion. The basic assessment, including the history and examination, ankle-brachial pressure index (ABPI), Duplex scan and tcPO 2 measurements, was performed on two occasions at the beginning of the trial and after three months.
      Results: The tcPO 2 level was low in the beginning in all the subjects, but the picture was different at the end of the trial. There was a significant increase in the tcPO 2 level (p<0.001) in the patients who performed exercise while there was no difference in the measurements (p>0.05) in the non-exercise group.
      Conclusions: Induced venous hypovolemia through regular evacuation of the peripheral venous system improved tissue oxygenation at skin level. Venous hypervolemia may be the main contributing factor for the development of venous hypoxia and microvascular ischemia.
    • Contributed Indexing:
      Keywords: exercise; hypervolemia; hypoxia; ulcer; venous
    • Publication Date:
      Date Created: 20180802 Date Completed: 20190315 Latest Revision: 20190315
    • Publication Date:
      20221213
    • Accession Number:
      10.1177/0267659118791682
    • Accession Number:
      30067139