[Severe acute alcoholic hepatitis].

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  • Additional Information
    • Transliterated Title:
      Hépatite alcoolique aiguë sévère.
    • Source:
      Publisher: Elsevier Masson Country of Publication: France NLM ID: 8302490 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-0276 (Electronic) Linking ISSN: 07554982 NLM ISO Abbreviation: Presse Med Subsets: MEDLINE
    • Publication Information:
      Publication: <2012- > : Paris : Elsevier Masson
      Original Publication: Paris ; New York : Masson, [c1983-
    • Subject Terms:
      Acute Disease* ; Hepatitis, Alcoholic*/diagnosis ; Hepatitis, Alcoholic*/physiopathology ; Hepatitis, Alcoholic*/therapy; Algorithms ; Humans ; Prognosis ; Severity of Illness Index
    • Abstract:
      All chronic and excessive consumer of alcohol with recent jaundice should be assessed using a Maddrey's score for severe acute alcoholic hepatitis. Corticosteroids are the first line of treatment, associated with an appropriate nutritional support and alcohol abstinence. Corticosteroids plus N-acetylcysteine combination improves short-term survival over corticosteroids alone, and could be proposed as a first line therapy. The response to treatment is evaluated at the 7th day of treatment, with the Lille model≤0.45. Prognostic of non-responders to corticosteroids with Lille model>0.45 is dramatically low with 23% survival at 6 month. Early liver transplantation in a selected group of patients with non-response to corticosteroids significantly improves 6th month and long-term survival.
      (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
    • Publication Date:
      Date Created: 20180724 Date Completed: 20180927 Latest Revision: 20180927
    • Publication Date:
      20250114
    • Accession Number:
      10.1016/j.lpm.2018.05.013
    • Accession Number:
      30032921