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Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications.
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- Author(s): Greene DA; Lattimer SA
- Source:
Diabetes [Diabetes] 1986 Feb; Vol. 35 (2), pp. 242-5.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Print ISSN: 0012-1797 (Print) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
- Publication Information:
Publication: Alexandria, VA : American Diabetes Association
Original Publication: [New York, American Diabetes Association]
- Subject Terms:
- Abstract:
Diminished (Na,K)-ATPase activity in diabetic peripheral nerve is attributed to an underlying depletion of free myo-inositol, but no biochemical mechanism linking myo-inositol metabolism and (Na,K)-ATPase has emerged. Since inositol phospholipid turnover releases inositol-(1,4,5)-tris-phosphate and diacylglycerol, two putative "second messengers" that modulate protein kinase C, the effect of protein kinase C agonists on (Na,K)-ATPase activity was examined in diabetic nerve. Phorbol myristate acetate or the diacylglycerol sn-1,2-dioctanoylglycerol acutely normalized depressed ouabain-inhibitable respiration [a measure of (Na,K)-ATPase activity], suggesting that myo-inositol metabolism modulates (Na,K)-ATPase activity via protein kinase C, and that reduced myo-inositol impairs (Na,K)-ATPase activity in diabetic nerve by this mechanism.
- Grant Information:
R01 AM29892 United States AM NIADDK NIH HHS
- Accession Number:
0 (Diglycerides)
0 (Glycerides)
0 (Phorbols)
1069-87-0 (1,2-dioctanoylglycerol)
4L6452S749 (Inositol)
5ACL011P69 (Ouabain)
EC 2.7.11.13 (Protein Kinase C)
EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
NI40JAQ945 (Tetradecanoylphorbol Acetate)
- Publication Date:
Date Created: 19860201 Date Completed: 19860310 Latest Revision: 20191210
- Publication Date:
20231215
- Accession Number:
10.2337/diab.35.2.242
- Accession Number:
3002888
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