HIV-1 Entry Inhibitors: A Review of Experimental and Computational Studies.

Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-

Drug Design*; HIV Fusion Inhibitors/*chemistry ; HIV Fusion Inhibitors/*pharmacology ; HIV Infections/*drug therapy ; HIV-1/*drug effects ; Small Molecule Libraries/*chemistry ; Small Molecule Libraries/*pharmacology; Animals ; HIV Envelope Protein gp120/antagonists & inhibitors ; HIV Envelope Protein gp120/metabolism ; HIV Envelope Protein gp41/antagonists & inhibitors ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/metabolism ; HIV-1/physiology ; Humans ; Receptors, CCR5/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Small Molecule Libraries/therapeutic use ; Virus Internalization/drug effects

The HIV-1 life cycle consists of different events, such as cell entry and fusion, virus replication, assembly and release of the newly formed virions. The more logical way to inhibit HIV transmission among individuals is to inhibit its entry into the immune host cells rather than targeting the intracellular viral enzymes. Both viral and host cell surface receptors and co-receptors are regarded as potential targets in anti-HIV-1 drug design process. Because of the importance of this topic it was decided to summarize recent reports on small-molecule HIV-1 entry inhibitors that have not been considered in the latest released reviews. All the computational studies reported in the literature regarding HIV-1 entry inhibitors since 2014 was also considered in this review.
(© 2018 Wiley-VHCA AG, Zurich, Switzerland.)

Keywords: CCR5; CXCR4; HIV-1-entry; anti-HIV agents; gp120; gp41

0 (CCR5 protein, human)
0 (CXCR4 protein, human)
0 (HIV Envelope Protein gp120)
0 (HIV Envelope Protein gp41)
0 (HIV Fusion Inhibitors)
0 (Receptors, CCR5)
0 (Receptors, CXCR4)
0 (Small Molecule Libraries)

Date Created: 20180721 Date Completed: 20181029 Latest Revision: 20181029

20221213

10.1002/cbdv.201800159

30027572