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Costs associated with long-acting insulin analogues in patients with diabetes.
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- Author(s): Alemayehu B;Alemayehu B; Speiser J; Bloudek L; Sarnes E
- Source:
The American journal of managed care [Am J Manag Care] 2018 Jul; Vol. 24 (8 Spec No.), pp. SP265-SP272.- Publication Type:
Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Clinical Care Targeted Communications Group, LLC Country of Publication: United States NLM ID: 9613960 Publication Model: Print Cited Medium: Internet ISSN: 1936-2692 (Electronic) Linking ISSN: 10880224 NLM ISO Abbreviation: Am J Manag Care
- Publication Information: Publication: Cranbury, NJ : Clinical Care Targeted Communications Group, LLC
Original Publication: Old Bridge, NJ : American Medical Pub., c1995- - Subject Terms: Cost-Benefit Analysis* ; Drug Costs*; Diabetes Mellitus, Type 1/*drug therapy ; Diabetes Mellitus, Type 2/*drug therapy ; Hypoglycemic Agents/*economics ; Insulin, Long-Acting/*economics; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin Glargine/administration & dosage ; Insulin Glargine/economics ; Insulin, Long-Acting/administration & dosage ; Male ; Quality-Adjusted Life Years ; United States
- Abstract: Objectives: The objective of this literature review was to evaluate the costs associated with the use of long-acting insulin analogues (LAIAs) compared with non-LAIA agents, including human insulin, oral antidiabetic drugs, and other injectable therapies, in the treatment of patients with type 1 diabetes (T1D) or type 2 diabetes (T2D).
Study Design: A systematic review of the medical literature (MEDLINE, EMBASE, Cochrane, EconLit) conducted from 2004 to 2016.
Methods: The review protocol was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria for studies were: patients with T1D and/or T2D, LAIA intervention, and comparators, including oral antidiabetics (OADs) or neutral protamine Hagedorn (NPH). Outcomes of interest were adherence measures; economic outcomes, including total costs, cost savings, and willingness-to-pay; and cost-effectiveness or incremental cost-effectiveness analyses. Real-world costs of individual LAIAs were also evaluated and are often compared against those of other LAIAs in the economic analyses.
Results: We identified and included 117 relevant studies. Patients using LAIAs had higher drug costs than those using OADs and NPH but had neutral or reduced total and diabetes-related costs compared with patients using non-LAIAs. Use of LAIA pen-delivery systems may lead to improved adherence and reduction in costs. Patients receiving insulin glargine demonstrated higher adherence and persistence than patients on insulin detemir. Economic models suggest that LAIAs are more cost-effective than NPH for T1D; for T2D, insulin glargine is more costly than NPH but less so than insulin detemir.
Conclusions: Despite higher drug costs, the real-world overall medical costs of LAIAs are not significantly different from those of NPH in patients with diabetes. The findings may be helpful for formulary decision making for patients with diabetes in a cost-constrained environment. - Accession Number: 0 (Hypoglycemic Agents)
0 (Insulin, Long-Acting)
2ZM8CX04RZ (Insulin Glargine) - Publication Date: Date Created: 20180719 Date Completed: 20200214 Latest Revision: 20200214
- Publication Date: 20221213
- Accession Number: 30020738
- Source:
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