Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology.

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  • Author(s): Muscher-Banse AS;Muscher-Banse AS; Breves G; Breves G
  • Source:
    Pflugers Archiv : European journal of physiology [Pflugers Arch] 2019 Jan; Vol. 471 (1), pp. 185-191. Date of Electronic Publication: 2018 Jul 16.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 0154720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2013 (Electronic) Linking ISSN: 00316768 NLM ISO Abbreviation: Pflugers Arch Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer.
    • Subject Terms:
      Intestinal Absorption* ; Renal Reabsorption*; Epithelial Cells/*metabolism ; Phosphates/*metabolism ; Ruminants/*metabolism ; Solute Carrier Proteins/*metabolism; Adaptation, Physiological ; Animals ; Homeostasis ; Phosphates/blood ; Ruminants/physiology
    • Abstract:
      Ruminants have a unique utilization of phosphate (P i ) based on the so-called endogenous P i recycling to guarantee adequate P i supply for ruminal microbial growth and for buffering short-chain fatty acids. Large amounts of P i enter the gastrointestinal tract by salivary secretion. The high saliva P i concentrations are generated by active secretion of P i from blood into primary saliva via basolateral sodium (Na + )-dependent P i transporter type II. The following subsequent intestinal absorption of P i is mainly carried out in the jejunum by the apical located secondary active Na + -dependent P i transporters NaPi IIb (SLC34A2) and PiT1 (SLC20A1). A reduction in dietary P i intake stimulates the intestinal P i absorption by increasing the expression of NaPi IIb despite unchanged plasma 1,25-dihydroxyvitamin D 3 concentrations, which modulate P i homeostasis in monogastric species. Reabsorption of glomerular filtrated plasma P i is mainly mediated by the P i transporters NaPi IIa (SLC34A1) and NaPi IIc (SLC34A3) in proximal tubule apical cells. The expression of NaPi IIa and the corresponding renal Na + -dependent P i capacity were modulated by high dietary phosphorus (P) intake in a parathyroid-dependent manner. In response to reduced dietary P i intake, the expression of NaPi IIa was not adapted indicating that renal P i reabsorption in ruminants runs at a high level allowing no further increase when P intake is diminished. In bones and in the mammary glands, Na + -dependent P i transporters are able to contribute to maintaining P i homeostasis. Overall, the regulation of P i transporter activity and expression by hormonal modulators confirms substantial differences between ruminant and non-ruminant species.
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    • Contributed Indexing:
      Keywords: 1,25-dihydroxyvitamin D 3; Goat; NaPi IIa; NaPi IIb; PTH; Phosphate; PiT1
    • Accession Number:
      0 (Phosphates)
      0 (Solute Carrier Proteins)
    • Publication Date:
      Date Created: 20180717 Date Completed: 20200213 Latest Revision: 20200306
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00424-018-2181-5
    • Accession Number:
      30009339