Polycystic ovary syndrome (PCOS) and kisspeptin - A Sri Lankan study.

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  • Additional Information
    • Source:
      Publisher: Medknow Publications Country of Publication: India NLM ID: 2985196R Publication Model: Print Cited Medium: Internet ISSN: 0972-2823 (Electronic) Linking ISSN: 00223859 NLM ISO Abbreviation: J Postgrad Med Subsets: MEDLINE
    • Publication Information:
      Publication: Mumbai : Medknow Publications
      Original Publication: Bombay, India.
    • Subject Terms:
      Gonadotropin-Releasing Hormone/*genetics ; Kisspeptins/*blood ; Polycystic Ovary Syndrome/*genetics ; Receptors, Kisspeptin-1/*genetics; Adolescent ; Adult ; Body Mass Index ; Case-Control Studies ; Female ; Humans ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/ethnology ; Sri Lanka/epidemiology ; Young Adult
    • Abstract:
      Context: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic-pituitary-gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels.
      Aim: We aimed to measure serum kisspeptin levels of subjects with well-characterized PCOS versus controls and explore any correlation between kisspeptin and PCOS-related reproductive and metabolic disturbances.
      Materials and Methods: : Consecutive women with PCOS manifesting from adolescence (n = 55) and adult controls (n = 110) were recruited. Pre-treatment baseline clinical, anthropometry, and biochemical parameters were measured in all. Serum kisspeptin and testosterone levels were determined by enzyme-linked immunosorbent assay method.
      Results: : Serum kisspeptin and testosterone concentrations were significantly higher in women with PCOS (kisspeptin 4.873 nmol/L; testosterone 4.713 nmol/L) than controls (kisspeptin 4.127 nmol/L; testosterone 3.415 nmol/L; P < 0.05). Serum kisspeptin levels were positively associated with PCOS (odds ratio: 1.853; 95% confidence interval: 1.246-2.755; P = 0.002) in our studied population.
      Conclusion: Serum kisspeptin levels are higher in Sri Lankan women with PCOS manifesting from adolescence compared with controls regardless of body mass index. We propose serum kisspeptin concentration as a useful marker to recognize PCOS that manifests from adolescence.
      Competing Interests: None
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    • Contributed Indexing:
      Keywords: Adolescence; GPR54; KISS1; kisspeptin; polycystic ovary syndrome
    • Accession Number:
      0 (KISS1 protein, human)
      0 (KISS1R protein, human)
      0 (Kisspeptins)
      0 (Receptors, Kisspeptin-1)
      33515-09-2 (Gonadotropin-Releasing Hormone)
    • Publication Date:
      Date Created: 20180714 Date Completed: 20200521 Latest Revision: 20200521
    • Publication Date:
      20231215
    • Accession Number:
      PMC6380135
    • Accession Number:
      10.4103/jpgm.JPGM_683_17
    • Accession Number:
      30004037