[Hypolipidemic effect of Coptis chinensis and C. deltoidea on type 2 diabetes rats through SCAP/SREBP-1c signal pathway].

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  • Additional Information
    • Source:
      Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo
      Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989-
    • Subject Terms:
      Signal Transduction*; Coptis/*chemistry ; Diabetes Mellitus, Type 2/*drug therapy ; Hypoglycemic Agents/*pharmacology ; Plant Extracts/*pharmacology; Animals ; Coptis/classification ; Diabetes Mellitus, Experimental/drug therapy ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/metabolism ; Rats ; Sterol Regulatory Element Binding Protein 1/metabolism
    • Abstract:
      The type 2 diabetes rat model was induced with high-sugar and high-fat diet combined with low-dose STZ. This study investigated the hypolipidemic mechanism of Coptis chinensis and C. deltoidea. After 30 days of administration, HOMA-IR and the content of TG in serum were detected, and the expressions of SCAP, SREBP-1c were tested by the method of Western blot and Real-time PCR analysis. The test results showed that both components can significantly alleviate insulin resistance and down-regulate the expressions of SREBP-1c and SCAP in liver tissue of type two diabetes mellitus. Compared with the control group, there were significant differences in relevant protein expression ( P <0.05, P <0.01). This indicates that the inhibition of SREBP-1c and SCAP expressions may be the hypolipidemic mechanism of Coptidis Rhizoma on type 2 diabetes mellitus. The results also showed that C. deltoidea has a better efficacy in lipid elimination, but a weaker hypoglycemic effect against C. chinensis.
      Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
      (Copyright© by the Chinese Pharmaceutical Association.)
    • Contributed Indexing:
      Keywords: Coptis chinensis; Coptis deltoidea; insulin resistance; lipid metabolism; signal pathway; type 2 diabetes mellitus
    • Accession Number:
      0 (Hypoglycemic Agents)
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Membrane Proteins)
      0 (Plant Extracts)
      0 (SREBP cleavage-activating protein)
      0 (Srebf1 protein, rat)
      0 (Sterol Regulatory Element Binding Protein 1)
    • Publication Date:
      Date Created: 20180624 Date Completed: 20190717 Latest Revision: 20190717
    • Publication Date:
      20231215
    • Accession Number:
      10.19540/j.cnki.cjcmm.20180208.003
    • Accession Number:
      29933682