Scaffolds for peripheral nerve repair and reconstruction.

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  • Author(s): Yi S;Yi S; Xu L; Xu L; Gu X; Gu X
  • Source:
    Experimental neurology [Exp Neurol] 2019 Sep; Vol. 319, pp. 112761. Date of Electronic Publication: 2018 Jun 02.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
    • Publication Information:
      Publication: Orlando Fl : Academic Press
      Original Publication: New York.
    • Subject Terms:
      Tissue Scaffolds*; Nerve Tissue/*transplantation ; Peripheral Nerve Injuries/*therapy ; Tissue Engineering/*methods; Animals ; Biocompatible Materials ; Humans ; Nerve Regeneration
    • Abstract:
      Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous nerve grafting, the current gold standard technique for the treatment of peripheral nerve injury, has many internal disadvantages. Emerging studies showed that tissue engineered nerve graft is an effective substitute to autologous nerves. Tissue engineered nerve graft is generally composed of neural scaffolds and incorporating cells and molecules. A variety of biomaterials have been used to construct neural scaffolds, the main component of tissue engineered nerve graft. Synthetic polymers (e.g. silicone, polyglycolic acid, and poly(lactic-co-glycolic acid)) and natural materials (e.g. chitosan, silk fibroin, and extracellular matrix components) are commonly used along or together to build neural scaffolds. Many other materials, including the extracellular matrix, glass fabrics, ceramics, and metallic materials, have also been used to construct neural scaffolds. These biomaterials are fabricated to create specific structures and surface features. Seeding supporting cells and/or incorporating neurotrophic factors to neural scaffolds further improve restoration effects. Preliminary studies demonstrate that clinical applications of these neural scaffolds achieve satisfactory functional recovery. Therefore, tissue engineered nerve graft provides a good alternative to autologous nerve graft and represents a promising frontier in neural tissue engineering.
      (Copyright © 2018 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Biomaterials; Clinical applications; Neural scaffold; Peripheral nerve repair; Scaffold fabrication; Tissue engineered nerve graft
    • Accession Number:
      0 (Biocompatible Materials)
    • Publication Date:
      Date Created: 20180518 Date Completed: 20200224 Latest Revision: 20200224
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.expneurol.2018.05.016
    • Accession Number:
      29772248