[Drugs for intravenous induction of anesthesia: barbiturates].

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  • Additional Information
    • Transliterated Title:
      Medikamente zur intravenösen Narkoseinduktion: Barbiturate.
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0370525 Publication Model: Print Cited Medium: Internet ISSN: 1432-055X (Electronic) Linking ISSN: 00032417 NLM ISO Abbreviation: Anaesthesist Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, Springer-Verlag.
    • Subject Terms:
      Barbiturates/*pharmacokinetics ; Barbiturates/*pharmacology; Anesthesia, Intravenous ; Anesthesia, Obstetrical ; Cesarean Section ; GABA-A Receptor Agonists ; Humans ; Methohexital ; Receptors, GABA-A ; Thiopental
    • Abstract:
      The discovery of barbituric acid and research on its derivatives have long been of importance in advancements in modern anesthesia. Decades of clinical use of barbiturates worldwide and their abuse has led to an enormous amount of knowledge. Thiopental and methohexital are ultra-short acting derivatives of barbiturates. Their clinical application has been accompanied by an enormous increase in the knowledge of the pharmacology of cerebrally active drugs, in particular gamma-aminobutyric acid (GABA A ) receptor and GABA-induced effects on nerve cell membranes. Despite the development of newer substances, thiopental still has a firm place in clinical applications. Currently it is mainly used in obstetrics for induction of cesarean sections under general anesthesia. A disadvantage, when properly used to induce anesthesia, is usually only the prolonged elimination kinetics of barbiturates. It is beneficial that barbiturates do not require side effect provoking solubilizers.
    • Comments:
      Comment in: Anaesthesist. 2018 Jul;67(7):533-534. (PMID: 29802439)
    • References:
      Curr Opin Anaesthesiol. 2015 Dec;28(6):656-61. (PMID: 26539786)
      Br J Anaesth. 2013 Jun;110 Suppl 1:i113-20. (PMID: 23562933)
      Anesthesiology. 1976 Dec;45(6):656-60. (PMID: 984482)
      Br J Anaesth. 1980 Aug;52(8):759-62. (PMID: 7426253)
      Crit Rev Toxicol. 2013 Aug;43(7):537-58. (PMID: 23875763)
      J Pharmacol Exp Ther. 1951 Aug;102(4):215-8. (PMID: 14861757)
      Anaesthesist. 2011 Oct;60(10):916-28. (PMID: 21833754)
      J Clin Med. 2016 May 19;5(5):. (PMID: 27213459)
      Br J Anaesth. 1994 May;72(5):596-8. (PMID: 8198916)
      Can J Anaesth. 1993 Jan;40(1):10-2. (PMID: 8425236)
      Eur J Clin Pharmacol. 1998 Sep;54(7):529-34. (PMID: 9832294)
      Anaesthesist. 2011 Sep;60(9):819-26. (PMID: 21509574)
      Epilepsia. 2012 Dec;53 Suppl 8:12-25. (PMID: 23205959)
      Br Med J. 1969 May 31;2(5656):540-3. (PMID: 5769887)
      Curr Opin Anaesthesiol. 2015 Jun;28(3):240-6. (PMID: 25827280)
      Anaesthesist. 2014 May;63(5):415-21. (PMID: 24615229)
      Br Med J. 1955 Nov 26;2(4951):1308-9. (PMID: 13269858)
      J Clin Neurophysiol. 2016 Feb;33(1):22-4. (PMID: 26840873)
      Anasthesiol Intensivmed Notfallmed Schmerzther. 1994 Nov;29(7):400-7. (PMID: 7819465)
      J Clin Anesth. 2000 Feb;12(1):25-30. (PMID: 10773504)
      Clin Pharmacokinet. 1998 Aug;35(2):95-134. (PMID: 9739479)
      Anesth Analg. 1993 Jan;76(1):10-7. (PMID: 8418708)
      Can J Anaesth. 1989 Sep;36(5):526-9. (PMID: 2791176)
      Br J Anaesth. 1980 Oct;52(10):1005-8. (PMID: 7437208)
      Annu Rev Pharmacol Toxicol. 1982;22:245-77. (PMID: 6282187)
      Br J Anaesth. 1956 Aug;28(8):344-52. (PMID: 13355914)
      Cochrane Database Syst Rev. 2012 Dec 12;12:CD000033. (PMID: 23235573)
      Can Anaesth Soc J. 1986 Jul;33(4):427-32. (PMID: 3742316)
      Br J Hosp Med (Lond). 2008 Sep;69(9):541. (PMID: 18819313)
      Int J Obstet Anesth. 2013 Jan;22(1):31-5. (PMID: 23122280)
      Anaesthesist. 2002 May;51(5):409-17. (PMID: 12125314)
      Anesth Analg. 1991 Jan;72(1):28-35. (PMID: 1984373)
      Anesth Analg. 2016 Nov;123(5):1263-1273. (PMID: 27167687)
      Anesth Analg. 1998 Jan;86(1):208-13. (PMID: 9428880)
      Int J Obstet Anesth. 2013 Jul;22(3):175-8. (PMID: 23711759)
      Anesthesiology. 1983 Aug;59(2):123-6. (PMID: 6869869)
      Acta Anaesthesiol Scand. 1987 Jan;31(1):30-2. (PMID: 3825473)
      Anaesthesia. 1982 Jul;37(7):726-34. (PMID: 7048989)
      Epilepsia. 2002 Feb;43(2):146-53. (PMID: 11903460)
      Mayo Clin Proc. 2005 Jun;80(6):783-95. (PMID: 15945530)
      Anesthesiology. 2013 Jun;118(6):1408-16. (PMID: 23422796)
      Anaesthesist. 2014 Jun;63(6):488-95. (PMID: 24820355)
      J Pharm Sci. 1983 Aug;72(8):937-40. (PMID: 6620152)
      Br J Anaesth. 2010 Dec;105 Suppl 1:i16-23. (PMID: 21148651)
      Anesth Prog. 1991 Nov-Dec;38(6):195-9. (PMID: 1842156)
      Anesthesiology. 1991 Dec;75(6):940-4. (PMID: 1741514)
      Anaesthesist. 1992 Apr;41(4):171-8. (PMID: 1590573)
      Clin Pharmacokinet. 2005;44(10):1051-65. (PMID: 16176118)
      Acta Pharmacol Toxicol (Copenh). 1980 Jul;47(1):24-32. (PMID: 7395522)
      Arch Pediatr Adolesc Med. 2001 Jun;155(6):665-8. (PMID: 11386953)
      Anaesthesist. 2006 Mar;55(3):287-95. (PMID: 16315024)
      Anesthesiology. 2010 Jan;112(1):86-101. (PMID: 19952722)
      Neuropsychiatr Dis Treat. 2005 Dec;1(4):329-43. (PMID: 18568113)
    • Contributed Indexing:
      Keywords: Cesarean section; Methohexital; Pharmacodynamics; Pharmacokinetics; Thiopental
    • Accession Number:
      0 (Barbiturates)
      0 (GABA-A Receptor Agonists)
      0 (Receptors, GABA-A)
      E5B8ND5IPE (Methohexital)
      JI8Z5M7NA3 (Thiopental)
    • Publication Date:
      Date Created: 20180511 Date Completed: 20200106 Latest Revision: 20200306
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00101-018-0440-7
    • Accession Number:
      29744526